SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0DHB7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHSD17B7
Description3-keto-steroid reductase (ec 1.1.1.270) (estradiol 17-beta- dehydrogenase 7) (ec 1.1.1.62) (17-beta-hsd 7) (17-beta-hydroxysteroid dehydrogenase 7).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004303 estradiol 17-beta-dehydrogenase activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes.ost of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterized was Drosophila alcohol dehydrogenase.his family used to be called insect-type.r short-chain alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains .he first binding the coenzyme.ften NAD.nd the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity.nd it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains .
  IPR002198:Short-chain dehydrogenase/reductase SDR
Glucose dehydrogenase catalyses the oxidation of D-glucose without priorphosphorylation to D-beta-gluconolactone using NAD or NADP as a coenzyme.The enzyme is a tetrameric protein.ach of the 4 identical subunitscontaining 262 amino acid residues. This family is a subset of a more general family of short-chain dehydrogenases andreductases.A match to this extension indicates that the protein is notan alcohol dehydrogenase.ut another type of dehydrogenaseor reductase.
  IPR002347:Glucose/ribitol dehydrogenase
IPR002198:adh_short 
Evalue:-12.8239088058472 
Location:3-93IPR002347:ADH_short 
Evalue:0 
Location:124-288IPR002198:ADH_SHORT 
Evalue:0 
Location:0-0
SequencesProtein: DHB7_HUMAN (341 aa)
mRNA: AK022929 NM_016371
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentK00044
  Level 3 annotation:
    estradiol 17beta-dehydrogenase
  Level 2 annotation:
    Androgen and estrogen metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 45 residues, 161027115-161027249Exon2: 70 residues, 161029072-161029276Exon3: 33 residues, 161032998-161033091Exon4: 380 residues, 161034215-161035349Exon5: 67 residues, 161036156-161036351Exon6: 37 residues, 161039844-161039949Exon7: 21 residues, 161040680-161040737Exon8: 35 residues, 161041807-161041906Exon9: 175 residues, 161048711-161049231Exon10: 2 residues, -Jump to DHB7_HUMANExon1: 44 residues, 161027119-161027249Exon2: 70 residues, 161029072-161029276Exon3: 33 residues, 161032998-161033091Exon4: 40 residues, 161034215-161034330Exon5: 67 residues, 161036156-161036351Exon6: 37 residues, 161039844-161039949Exon7: 21 residues, 161040680-161040737Exon8: 35 residues, 161041807-161041906Exon9: 175 residues, 161048711-161049231Exon10: 2 residues, -Jump to DHB7_HUMAN  
Tune and view alternative isoforms