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0DGKZ_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionDiacylglycerol kinase, zeta (ec (diglyceride kinase) (dgk- zeta) (dag kinase zeta).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0005524 ATP binding (TAS)
0004143 diacylglycerol kinase activity (TAS)
0007165 signal transduction (TAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumor promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases.ollectively known as protein kinase C (PKC) . Phorbol esters can directly stimulate PKC. The N-terminal region of PKC.nown as been shown to bind PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain.hich is about 50 amino-acid residues long.nd which is essential for DAG/PE-binding. The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.
  IPR002219:Protein kinase C, phorbol ester/diacylglycerol binding
Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The DAGkinase domain is assumed to be an accessory domain. Upon cell stimulation.AG kinase convertsDAG into phosphatidate.nitiating the resynthesis of phosphatidylinositols and attenuatingprotein kinase C activity. It catalyzes the reaction: ATP + 1.-diacylglycerol = ADP +1.-diacylglycerol 3-phosphate. The enzyme is stimulated by calcium and phosphatidylserineand phosphorylated by protein kinase C. This domain is always associated with .
  IPR000756:Diacylglycerol kinase accessory region
Diacylglycerol kinase (DGK. phosphorylates diacylglycerol (DAG) to yield phosphatidic acid. This enzyme initiates resynthesis of phosphoinositides consumed by phospholipase C during cellular signal transduction. Mammalian DGK consists of nine isozymes encoded by separate genes . In addition to PKC-like zinc fingers and catalytic regions commonly conserved in all DGKs.hese isozymes contain a variety of regulatory domains of known and/or predicted functions. The mammalian isozymes are named according to the order of their cDNA cloning and are subdivided into five groups based on their characteristic structural features. Each DGK isozyme is a critical downstream component of a DAG-dependent signaling system. This domain is usually associated with an accessory domain (see ).
  IPR001206:Diacylglycerol kinase, catalytic region
The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers . The repeat has been found in proteins of diverse function such as transcriptional initiators.ell-cycle regulators.ytoskeletal.on transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures . Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure .
SequencesProtein: DGKZ_HUMAN (1117 aa)
mRNA: U94905
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK00901
  Level 3 annotation:
    diacylglycerol kinase
  Level 2 annotation:
    Glycerolipid metabolism
    Glycerophospholipid metabolism
    Phosphatidylinositol signaling system
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 51 residues, 46323559-46323711Exon2: 38 residues, 46345416-46345525Exon3: 510 residues, 46345777-46347301Exon4: 2 residues, -Jump to Q6ZWA5_HUMANExon1: 38 residues, 46339720-46339832Exon2: 249 residues, 46344369-46345110Exon3: 38 residues, 46345416-46345525Exon4: 34 residues, 46345777-46345873Exon5: 27 residues, 46346130-46346205Exon6: 21 residues, 46347619-46347676Exon7: 25 residues, 46348066-46348135Exon8: 26 residues, 46349438-46349510Exon9: 41 residues, 46349612-46349729Exon10: 26 residues, 46349829-46349901Exon11: 34 residues, 46350200-46350296Exon12: 29 residues, 46350553-46350636Exon13: 22 residues, 46350742-46350803Exon14: 40 residues, 46350896-46351010Exon15: 49 residues, 46351086-46351227Exon16: 28 residues, 46352282-46352361Exon17: 20 residues, 46352524-46352580Exon18: 23 residues, 46352729-46352792Exon19: 26 residues, 46352891-46352965Exon20: 39 residues, 46353059-46353171Exon21: 68 residues, 46353557-46353757Exon22: 35 residues, 46353976-46354077Exon23: 28 residues, 46354191-46354271Exon24: 25 residues, 46354453-46354523Exon25: 15 residues, 46354649-46354690Exon26: 48 residues, 46355198-46355338Exon27: 12 residues, 46356323-46356355Exon28: 16 residues, 46356582-46356626Exon29: 42 residues, 46357116-46357237Exon30: 13 residues, 46357328-46357362Exon31: 35 residues, 46357594-46357694Exon32: 243 residues, 46357956-46358680Exon33: 2 residues, -Jump to DGKZ_HUMAN  
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Loci Cluster (Details)Loci: 2662 45863777-45884591 ~-21K 6614(MAPK8IP1)(+)Loci: 2663 46323559-46358680 ~-35K 6625(+)Loci: 3947 46363215-46364683 ~-1K 6632(CHRM4)(-)Loci: 2661 45825604-45861372 ~-36K 6612(+)Link out to UCSC