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0DEST_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionDestrin (actin-depolymerizing factor) (adf).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The ADF/cofilins are a family of actin-binding proteins expressed in all eukaryotic cells so far examined. Members of this family remodel the actin cytoskeleton.or example during cytokinesis.hen the actin-rich contractile ring shrinks as it contracts through the interaction of ADF/cofilins with both monomeric and filamentous actin. ADF/cofilins sever actin filaments (F-actin) and/or bind to actin monomers.r G-actin.hus preventing actin-polymerization by sequestering the monomers. The ADF/cofilins are formed by a single folded domain.he ADF homology domain.hich is also found in other actin-binding protein families and is the most conserved region of these proteins consisting of a twenty amino-acid segment that ends some 30 residues from their C-terminal extremity . The main actin-binding structure being a long alpha-helix. Plants and animals have multiple ADF/cofilin genes.elonging in vertebrates to two types.DF and cofilins. Other eukaryotes (such as yeast.canthamoeba and slime moulds) have a single ADF/cofilin gene. The following proteins are evolutionary related and belong to a family of low molecular weight (137 to 166 residues) actin-depolymerizing proteins .Cofilin from vertebrates.lime mold and yeast. Cofilin binds to F-actin and acts as a pH-dependent actin-depolymerizing protein.Destrin from vertebrates. Destrin binds to G-actin in a pH-independent manner and prevents polymerization.Caenorhabditis elegans unc-60.Acanthamoeba castellanii actophorin.Plants actin depolymerizing factor (ADF).
  IPR002108:Actin-binding, cofilin/tropomyosin type
SequencesProtein: DEST_HUMAN (164 aa)
mRNA: NM_001011546 NM_006870
Local Annotation
Synapse Ontology
actin exists in two states within the cell: as polymerized two-stranded helical filaments (F-actin) or as monomers (Gactin), which provide the building blocks for filament assembly.
sdb:0283 G-actin  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 87 residues, 17498598-17498856Exon2: 104 residues, 17529382-17529690Exon3: 27 residues, 17533199-17533276Exon4: 325 residues, 17535681-17536651Exon5: 2 residues, -Jump to DEST_HUMANExon1: 87 residues, 17498598-17498856Exon2: 46 residues, 17520576-17520708Exon3: 104 residues, 17529382-17529690Exon4: 27 residues, 17533199-17533276Exon5: 325 residues, 17535681-17536651Exon6: 2 residues, -Jump to DEST_HUMAN  
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Loci Cluster (Details)Loci: 4511 17870245-17897490 ~-27K 22737(SNX5)(-)Loci: 3241 17498598-17536651 ~-38K 22733(DSTN)(+)Link out to UCSC