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0DESP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDSP
DescriptionDesmoplakin (dp) (250/210 kda paraneoplastic pemphigus antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005200 structural constituent of cytoskeleton (TAS)
0008544 epidermis development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Plectin may have a role in cross-linking intermediate filaments.n inter-linking intermediate filaments with microtubules and microfilaments and in anchoring intermediate filaments to the plasma and nuclear membranes. Plectin is recruited into hemidesmosomes multiprotein complexes that facilitate adhesion of epithelia to the basement membrane.hereby providing linkage between the intracellular keratin filaments to the laminins of the extracellular matrix. Plectin binds to hemidesmosomes through association of its actin-binding domain with the first pair of fibronectin type III repeats and a small part of the connecting segment of the integrin-beta4 subunit.he latter (integrin-alpha6.eta4) acting as a receptor for the extracellular matrix component laminin-5.The plectin repeat is also seen in the cell adhesion junction plaque proteins.esmoplakin.nvoplakin.nd bullous pemphigoid antigen. The domains in plakins show considerable sequence homology. The N-terminus consists of a plakin domain containing a number of subdomains with high alpha-helical content.hile the central coiled-coil domain is composed of heptad repeats involved in the dimerisation of plakin.nd the C-terminus contains one or more homologous repeat sequences referred to plectin repeats . This entry represents the plectin repeats found in the C-terminus of plakin proteins.
  IPR001101:Plectin repeat
Spectrin repeats are found in several proteins involved incytoskeletal structure. These include spectrin.lpha-actininand dystrophin. The spectrin repeat forms athree helix bundle. The second helix is interrupted by prolinein some sequences. The repeats are defined by a characteristictryptophan (W) residue at position 17 in helix A and a leucine(L) at 2 residues from the carboxyl end of helix C.
  IPR002017:Spectrin repeat
IPR001101:Plectin 
Evalue:-19.050609588623 
Location:2365-2409IPR001101:Plectin 
Evalue:-18.5850257873535 
Location:2046-2090IPR001101:Plectin 
Evalue:-17.6989707946777 
Location:2648-2692IPR001101:Plectin 
Evalue:-16.1611499786377 
Location:2724-2768IPR001101:Plectin 
Evalue:-12.408935546875 
Location:2122-2166IPR001101:Plectin 
Evalue:-10.5686359405518 
Location:2296-2333IPR001101:Plectin 
Evalue:-9.74472713470459 
Location:2458-2500IPR001101:PLEC 
Evalue:-7.92081875395237 
Location:2251-2288IPR001101:PLEC 
Evalue:-6.11350927482752 
Location:2610-2647IPR001101:PLEC 
Evalue:-3.44369749923271 
Location:2507-2544IPR002017:SPEC 
Evalue:-1.21467016498923 
Location:273-373IPR001101:PLEC 
Evalue:-1 
Location:2009-2045IPR002017:SPEC 
Evalue:0.0791812460476248 
Location:889-1018IPR002017:SPEC 
Evalue:0.531478917042255 
Location:181-270IPR001101:PLEC 
Evalue:1.75587485567249 
Location:2198-2233
SequencesProtein: DESP_HUMAN (2871 aa)
mRNA: NM_004415
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
A dendritic spine is a mushroom-shaped bud that protrudes from a dendrite and forms one half of a synapse, especially in synapses of the cortex. The dendrites of cortical neurons typically are densely covered with such spines, which enable single cells to receive input from thousands of others.
sdb:0134 dendritic spine  (Evidence:keywords)
cytoskeleton filaments is one kind of structural components to maintain synapse morphology and bear the related function which is connected with the synaptic morphology.
sdb:0280 cytoskeletal filaments  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 150 residues, 7486868-7487317Exon2: 36 residues, 7500949-7501052Exon3: 51 residues, 7503347-7503496Exon4: 60 residues, 7504457-7504632Exon5: 45 residues, 7507883-7508012Exon6: 19 residues, 7508967-7509018Exon7: 56 residues, 7510590-7510752Exon8: 37 residues, 7511608-7511713Exon9: 34 residues, 7512585-7512681Exon10: 44 residues, 7513012-7513138Exon11: 53 residues, 7513668-7513821Exon12: 53 residues, 7514417-7514572Exon13: 44 residues, 7515668-7515795Exon14: 69 residues, 7516614-7516816Exon15: 77 residues, 7517073-7517300Exon16: 57 residues, 7519317-7519484Exon17: 48 residues, 7519888-7520027Exon18: 66 residues, 7520526-7520720Exon19: 56 residues, 7521525-7521688Exon20: 30 residues, 7522190-7522274Exon21: 38 residues, 7523010-7523118Exon22: 35 residues, 7523695-7523794Exon23: 767 residues, 7524506-7526801Exon24: 1359 residues, 7527873-7531945Exon25: 2 residues, -Jump to DESP_HUMAN  
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Loci Cluster (Details)Loci: 3520 7486868-7531945 ~-45K 30281(DSP)(+)Loci: 3519 7335060-7363267 ~-28K 30277(RIOK1)(+)Link out to UCSC