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0DEPD5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDEPDC5
DescriptionDep domain containing protein 5.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a domain of unknown function present in signaling proteins including dishevelled.gl-10.nd pleckstrinproteins. Segment polarity dishevelled protein is required to establish coherent arrays of polarized cells andsegments in embryos.nd plays a role in wingless signaling. Egl-10 regulates G-protein signaling in the centralnervous system. Mammalian regulators of G-protein signaling also contain these domains.nd regulate signaltransduction by increasing the GTPase activity of G-protein alpha subunits.hereby driving them into theirinactive GDP-bound form.
  IPR000591:Pleckstrin/ G-protein, interacting region
Winged helix DNA-binding proteins share a related winged helix-turn-helix DNA-binding motif.here the "wings".r loops.re small beta-sheets. The winged helix motif consists of two wings (W1.2).hree alpha helices (H1.2.3) and three beta-sheets (S1.2.3) arranged in the order H1-S1-H2-H3-S2-W1-S3-W2 . The DNA-recognition helix makes sequence-specific DNA contacts with the major groove of DNA.hile the wings make different DNA contacts.ften with the minor groove or the backbone of DNA. Several winged-helix proteins display an exposed patch of hydrophobic residues thought to mediate protein-protein interactions.Many different proteins with diverse biological functions contain a winged helix DNA-binding domain.ncluding transcriptional repressors such as biotin repressor.exA repressor and the arginine repressor ; transcription factors such as the hepatocyte nuclear factor-3 proteins involved in cell differentiation.eat-shock transcription factor.nd the general transcription factors TFIIE and TFIIF . helicases such as RuvB that promotes branch migration at the Holliday junction.nd CDC6 in the pre-replication complex . endonucleases such as FokI and TnsA ; histones; and Mu transposase.here the flexible wing of the enhancer-binding domain is essential for efficient transposition .
  IPR011991:Winged helix repressor DNA-binding
IPR000591:DEP 
Evalue:-21.508638381958 
Location:1156-1229
SequencesProtein: DEPD5_HUMAN (1572 aa)
mRNA: AJ698950 NM_014662
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 28 residues, 30480068-30480150Exon2: 41 residues, 30480847-30480965Exon3: 31 residues, 30484531-30484619Exon4: 17 residues, 30486641-30486688Exon5: 30 residues, 30490960-30491046Exon6: 30 residues, 30492570-30492654Exon7: 18 residues, 30494799-30494849Exon8: 25 residues, 30504084-30504154Exon9: 28 residues, 30509892-30509971Exon10: 22 residues, 30510799-30510861Exon11: 25 residues, 30518018-30518088Exon12: 26 residues, 30518730-30518803Exon13: 36 residues, 30523585-30523689Exon14: 27 residues, 30524567-30524642Exon15: 47 residues, 30528689-30528824Exon16: 22 residues, 30530147-30530209Exon17: 26 residues, 30530827-30530901Exon18: 25 residues, 30532107-30532177Exon19: 14 residues, 30535596-30535633Exon20: 42 residues, 30536506-30536627Exon21: 75 residues, 30540977-30541198Exon22: 70 residues, 30545007-30545211Exon23: 47 residues, 30547487-30547623Exon24: 34 residues, 30548678-30548776Exon25: 24 residues, 30559900-30559966Exon26: 54 residues, 30562984-30563141Exon27: 55 residues, 30564670-30564831Exon28: 41 residues, 30569080-30569198Exon29: 58 residues, 30569630-30569798Exon30: 75 residues, 30571003-30571223Exon31: 46 residues, 30572819-30572953Exon32: 38 residues, 30583430-30583539Exon33: 53 residues, 30596575-30596730Exon34: 28 residues, 30599240-30599318Exon35: 46 residues, 30600258-30600391Exon36: 38 residues, 30602142-30602251Exon37: 78 residues, 30605510-30605738Exon38: 58 residues, 30619567-30619737Exon39: 59 residues, 30623467-30623639Exon40: 22 residues, 30627727-30627788Exon41: 29 residues, 30631969-30632052Exon42: 272 residues, 30632190-30633000Exon43: 2 residues, -Jump to DEPD5_HUMANExon1: 38 residues, 30480852-30480965Exon2: 31 residues, 30484531-30484619Exon3: 17 residues, 30486641-30486688Exon4: 30 residues, 30490960-30491046Exon5: 30 residues, 30492570-30492654Exon6: 18 residues, 30494799-30494849Exon7: 25 residues, 30504084-30504154Exon8: 28 residues, 30509892-30509971Exon9: 22 residues, 30510799-30510861Exon10: 25 residues, 30518018-30518088Exon11: 26 residues, 30518730-30518803Exon12: 36 residues, 30523585-30523689Exon13: 27 residues, 30524567-30524642Exon14: 47 residues, 30528689-30528824Exon15: 22 residues, 30530147-30530209Exon16: 26 residues, 30530827-30530901Exon17: 25 residues, 30532107-30532177Exon18: 14 residues, 30535596-30535633Exon19: 42 residues, 30536506-30536627Exon20: 75 residues, 30540977-30541198Exon21: 70 residues, 30545007-30545211Exon22: 47 residues, 30547487-30547623Exon23: 34 residues, 30548678-30548776Exon24: 24 residues, 30559900-30559966Exon25: 54 residues, 30562984-30563141Exon26: 55 residues, 30564670-30564831Exon27: 41 residues, 30569080-30569198Exon28: 58 residues, 30569630-30569798Exon29: 75 residues, 30571003-30571223Exon30: 46 residues, 30572819-30572953Exon31: 38 residues, 30583430-30583539Exon32: 24 residues, 30587353-30587419Exon33: 53 residues, 30596575-30596730Exon34: 28 residues, 30599240-30599318Exon35: 46 residues, 30600258-30600391Exon36: 38 residues, 30602142-30602251Exon37: 78 residues, 30605510-30605738Exon38: 58 residues, 30619567-30619737Exon39: 59 residues, 30623467-30623639Exon40: 22 residues, 30627727-30627788Exon41: 29 residues, 30631969-30632052Exon42: 138 residues, 30632190-30632599Exon43: 2 residues, -Jump to DEPD5_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3309 30480068-30633000 ~-153K 24579(DEPDC5)(+)Loci: 3310 30670478-30683589 ~-13K 24585(YWHAH)(+)Loci: 4563 30345379-30388195 ~-43K 24575(PISD)(-)Link out to UCSC