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0DDX39_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDDX39
DescriptionAtp-dependent helicase ddx39 (dead-box protein 39) (nuclear rna helicase urh49).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (ISS)
0004004 ATP-dependent RNA helicase activity (ISS)
0005515 protein binding (IPI)
0006406 mRNA-nucleus export (IGI)
0000398 nuclear mRNA splicing, via spliceosome (IGI)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR011545:DEAD/DEAH box helicase, N-terminal
This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR014001:DEAD-like helicases, N-terminal
The domain.hich defines this group of proteins is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit.ut an integral part of the helicase.The eukaryotic translation initiation factor 4A (eIF4A) is a member of the DEA(D/H)-box RNA helicase family This is a diverse group of proteins that couples an ATPase activity to RNA binding and unwinding. The structure of the carboxyl-terminal domain of eIF4A has been determined to 1.75 A resolution; it has a parallel alpha-beta topology that superimposes.ith minor variations.n the structures and conserved motifs of the equivalent domain in other.istantly related helicases .
  IPR001650:Helicase, C-terminal
IPR011545:DEAD 
Evalue:-56.3665313720703 
Location:68-237IPR001650:Helicase_C 
Evalue:-28.1249389648438 
Location:305-381
SequencesProtein: DDX39_HUMAN (427 aa)
mRNA: NM_005804
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 45 residues, 14380630-14380764Exon2: 51 residues, 14380848-14380996Exon3: 50 residues, 14381114-14381259Exon4: 38 residues, 14381347-14381457Exon5: 46 residues, 14381553-14381685Exon6: 41 residues, 14382027-14382146Exon7: 63 residues, 14382800-14382984Exon8: 33 residues, 14383317-14383410Exon9: 44 residues, 14384362-14384490Exon10: 72 residues, 14384824-14385036Exon11: 32 residues, 14391081-14391171Exon12: 2 residues, -Jump to DDX39_HUMAN  
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Loci Cluster (Details)Loci: 4372 14380630-14391171 ~-11K 18171(DDX39)(-)Loci: 3093 14430110-14443670 ~-14K 18178(+)Loci: 4373 14852137-14853264 ~-1K 18201(-)Loci: 4374 14921990-14944730 ~-23K 18203(SLC1A6)(-)Loci: 4375 15325340-15351603 ~-26K 18217(AKAP8)(-)Loci: 4376 15351858-15390833 ~-39K 18218(AKAP8L)(-)Loci: 3094 15699833-15700862 ~-1K 18230(OR10H2)(+)Loci: 4377 15778890-15779847 ~-1K 18231(OR10H1)(-)Loci: 3095 16083489-16105443 ~-22K 18238(RAB8A)(+)Loci: 3096 16169730-16207156 ~-37K 18242(AP1M1)(+)Loci: 4378 16333407-16443762 ~-110K 18245(EPS15L1)(-)Loci: 4371 14119550-14177997 ~-58K 18165(LPHN1)(-)Link out to UCSC