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0DDX20_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDDX20
DescriptionProbable atp-dependent rna helicase ddx20 (dead-box protein 20) (dead- box protein dp 103) (component of gems 3) (gemin-3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005856 cytoskeleton (TAS)
0005634 nucleus (TAS)
0004004 ATP-dependent RNA helicase activity (TAS)
0005515 protein binding (IPI)
0000244 assembly of spliceosomal tri-snRNP (TAS)
0006396 RNA processing (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR014001:DEAD-like helicases, N-terminal
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR011545:DEAD/DEAH box helicase, N-terminal
The domain.hich defines this group of proteins is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit.ut an integral part of the helicase.The eukaryotic translation initiation factor 4A (eIF4A) is a member of the DEA(D/H)-box RNA helicase family This is a diverse group of proteins that couples an ATPase activity to RNA binding and unwinding. The structure of the carboxyl-terminal domain of eIF4A has been determined to 1.75 A resolution; it has a parallel alpha-beta topology that superimposes.ith minor variations.n the structures and conserved motifs of the equivalent domain in other.istantly related helicases .
  IPR001650:Helicase, C-terminal
IPR014001:DEXDc 
Evalue:-43.2146701649892 
Location:81-279IPR001650:Helicase_C 
Evalue:-27.0969104766846 
Location:328-404
SequencesProtein: DDX20_HUMAN (824 aa)
mRNA: NM_007204
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 199 residues, 112099776-112100370Exon2: 33 residues, 112100790-112100885Exon3: 58 residues, 112103544-112103713Exon4: 40 residues, 112104618-112104733Exon5: 49 residues, 112104850-112104993Exon6: 48 residues, 112105131-112105270Exon7: 21 residues, 112105370-112105429Exon8: 29 residues, 112106399-112106482Exon9: 37 residues, 112106821-112106927Exon10: 36 residues, 112107050-112107152Exon11: 615 residues, 112109881-112111721Exon12: 2 residues, -Jump to DDX20_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3819 111843577-111848266 ~-5K 2174(ADORA3)(-)Loci: 2538 111963927-112057623 ~-94K 2175(RAP1A)(+)Loci: 2539 112099776-112111721 ~-12K 2178(DDX20)(+)Loci: 3820 112119976-112333300 ~-213K 2180(KCND3)(-)Loci: 2537 111793265-111806046 ~-13K 2169(ATP5F1)(+)Link out to UCSC