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0DDX1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDDX1
DescriptionAtp-dependent helicase ddx1 (ec 3.6.1.-) (dead-box protein 1) (dead- box protein-retinoblastoma) (dbp-rb).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008026 ATP-dependent helicase activity (NAS)
0003724 RNA helicase activity (TAS)
0007275 development (IEP)
0006446 regulation of translational initiation (NAS)
0007046 ribosome biogenesis (NAS)
0000245 spliceosome assembly (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR011545:DEAD/DEAH box helicase, N-terminal
This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR014001:DEAD-like helicases, N-terminal
The SPRY domain is of unknown function. Distant homologues are domains inbutyrophilin/marenostrin/pyrin .Ca2+-release from the sarcoplasmic or endoplasmic reticulum.he intracellular Ca2+ store.s mediated by the ryanodine receptor (RyR) and/or the inositol trisphosphate receptor (IP3R).
  IPR003877:SPla/RYanodine receptor SPRY
The domain.hich defines this group of proteins is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit.ut an integral part of the helicase.The eukaryotic translation initiation factor 4A (eIF4A) is a member of the DEA(D/H)-box RNA helicase family This is a diverse group of proteins that couples an ATPase activity to RNA binding and unwinding. The structure of the carboxyl-terminal domain of eIF4A has been determined to 1.75 A resolution; it has a parallel alpha-beta topology that superimposes.ith minor variations.n the structures and conserved motifs of the equivalent domain in other.istantly related helicases .
  IPR001650:Helicase, C-terminal
Phosphoglycerate kinase () (PGK) is an enzyme that catalyses the formation of ATP to ADP and vice versa. In the second step of the second phase in glycolysis..-diphosphoglycerate is converted to3-phosphoglycerate.orming one molecule of ATP. If the reverse were to occur.ne molecule of ADP would be formed. This reaction is essential in most cells for the generation of ATP in aerobes.or fermentation in anaerobes and for carbon fixation in plants. PGK is found in all living organisms and its sequence has been highly conserved throughout evolution. The enzyme exists as a monomer containing two nearly equal-sized domains that correspond to the N- and C-termini of the protein (the last 15 C-terminal residues loop back into the N-terminal domain). 3-phosphoglycerate (3-PG) binds to the N-terminal.hile the nucleotide substrates.gATP or MgADP.ind to the C-terminal domain of the enzyme. This extended two-domain structure is associated with large-scale hinge-bending conformational changes.imilar to those found in hexokinase . At the core of each domain is a 6-stranded parallel beta-sheet surrounded by alpha helices. Domain 1 has a parallel beta-sheet of six strands with an order of 342156.hile domain 2 has a parallel beta-sheet of six strands with an order of 321456. Analysis of the reversible unfolding of yeast phosphoglycerate kinase leads to the conclusion that the two lobes are capable of folding independently.onsistent with the presence of intermediates on the folding pathway with a single domain folded . Phosphoglycerate kinase (PGK) deficiency is associated with haemolytic anaemia and mental disorders in man .
  IPR001576:Phosphoglycerate kinase
IPR011545:DEAD 
Evalue:-57.6020584106445 
Location:26-418IPR001650:Helicase_C 
Evalue:-29.4202156066895 
Location:534-610IPR000629:DEAD_ATP_HELICASE 
Evalue:0 
Location:0-0
SequencesProtein: DDX1_HUMAN (740 aa)
mRNA: BC012739 NM_004939
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 102 residues, 15649220-15649524Exon2: 19 residues, 15652719-15652771Exon3: 23 residues, 15653064-15653128Exon4: 12 residues, 15654308-15654338Exon5: 34 residues, 15654949-15655046Exon6: 18 residues, 15657243-15657291Exon7: 30 residues, 15660122-15660206Exon8: 30 residues, 15660766-15660850Exon9: 27 residues, 15661388-15661465Exon10: 26 residues, 15662011-15662084Exon11: 27 residues, 15663524-15663601Exon12: 40 residues, 15663724-15663839Exon13: 48 residues, 15664749-15664888Exon14: 22 residues, 15670798-15670859Exon15: 35 residues, 15674818-15674917Exon16: 32 residues, 15675755-15675845Exon17: 65 residues, 15677782-15677971Exon18: 19 residues, 15678639-15678691Exon19: 51 residues, 15681010-15681157Exon20: 32 residues, 15684628-15684720Exon21: 26 residues, 15686019-15686092Exon22: 26 residues, 15686212-15686285Exon23: 16 residues, 15686371-15686414Exon24: 34 residues, 15687176-15687272Exon25: 42 residues, 15687564-15687685Exon26: 110 residues, 15688350-15688675Exon27: 2 residues, -Jump to DDX1_HUMANExon1: 18 residues, 15649473-15649524Exon2: 19 residues, 15652719-15652771Exon3: 23 residues, 15653064-15653128Exon4: 12 residues, 15654308-15654338Exon5: 34 residues, 15654949-15655046Exon6: 18 residues, 15657243-15657291Exon7: 30 residues, 15660122-15660206Exon8: 30 residues, 15660766-15660850Exon9: 27 residues, 15661388-15661465Exon10: 26 residues, 15662011-15662084Exon11: 27 residues, 15663524-15663601Exon12: 40 residues, 15663724-15663839Exon13: 48 residues, 15664749-15664888Exon14: 22 residues, 15670798-15670859Exon15: 35 residues, 15674818-15674917Exon16: 32 residues, 15675755-15675845Exon17: 65 residues, 15677782-15677971Exon18: 19 residues, 15678639-15678691Exon19: 51 residues, 15681010-15681157Exon20: 32 residues, 15684628-15684720Exon21: 26 residues, 15686019-15686092Exon22: 26 residues, 15686212-15686285Exon23: 16 residues, 15686371-15686414Exon24: 34 residues, 15687176-15687272Exon25: 42 residues, 15687564-15687685Exon26: 110 residues, 15688350-15688675Exon27: 2 residues, -Jump to DDX1_HUMAN  
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