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0DDX17_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDDX17
DescriptionProbable atp-dependent helicase ddx17 (ec 3.6.1.-) (dead-box protein 17) (rna-dependent helicase p72) (dead-box protein p72).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0003723 RNA binding (TAS)
0003724 RNA helicase activity (TAS)
0008186 RNA-dependent ATPase activity (TAS)
0006396 RNA processing (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR011545:DEAD/DEAH box helicase, N-terminal
This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR014001:DEAD-like helicases, N-terminal
The domain.hich defines this group of proteins is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit.ut an integral part of the helicase.The eukaryotic translation initiation factor 4A (eIF4A) is a member of the DEA(D/H)-box RNA helicase family This is a diverse group of proteins that couples an ATPase activity to RNA binding and unwinding. The structure of the carboxyl-terminal domain of eIF4A has been determined to 1.75 A resolution; it has a parallel alpha-beta topology that superimposes.ith minor variations.n the structures and conserved motifs of the equivalent domain in other.istantly related helicases .
  IPR001650:Helicase, C-terminal
IPR011545:DEAD 
Evalue:-71.853874206543 
Location:116-287IPR001650:Helicase_C 
Evalue:-33.8538703918457 
Location:358-434
SequencesProtein: DDX17_HUMAN (650 aa)
mRNA: BC000595 CR456432 NM_006386
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1001 residues, 37209390-37212391Exon2: 81 residues, 37213829-37214066Exon3: 22 residues, 37218006-37218066Exon4: 22 residues, 37219660-37219722Exon5: 39 residues, 37219971-37220082Exon6: 59 residues, 37220580-37220753Exon7: 55 residues, 37220836-37220997Exon8: 49 residues, 37221746-37221888Exon9: 24 residues, 37224035-37224101Exon10: 46 residues, 37224390-37224524Exon11: 35 residues, 37225350-37225450Exon12: 52 residues, 37227080-37227231Exon13: 122 residues, 37231901-37232262Exon14: 2 residues, -Jump to DDX17_HUMANExon1: 245 residues, 37211659-37212391Exon2: 81 residues, 37213829-37214066Exon3: 22 residues, 37218006-37218066Exon4: 22 residues, 37219660-37219722Exon5: 39 residues, 37219971-37220082Exon6: 59 residues, 37220580-37220753Exon7: 55 residues, 37220836-37220997Exon8: 49 residues, 37221746-37221888Exon9: 24 residues, 37224035-37224101Exon10: 46 residues, 37224390-37224524Exon11: 35 residues, 37225350-37225450Exon12: 52 residues, 37227080-37227231Exon13: 114 residues, 37231901-37232238Exon14: 2 residues, -Jump to DDX17_HUMANExon1: 218 residues, 37211739-37212391Exon2: 83 residues, 37213823-37214066Exon3: 22 residues, 37218006-37218066Exon4: 22 residues, 37219660-37219722Exon5: 39 residues, 37219971-37220082Exon6: 59 residues, 37220580-37220753Exon7: 55 residues, 37220836-37220997Exon8: 49 residues, 37221746-37221888Exon9: 24 residues, 37224035-37224101Exon10: 46 residues, 37224390-37224524Exon11: 35 residues, 37225350-37225450Exon12: 52 residues, 37227080-37227231Exon13: 28 residues, 37231901-37231981Exon14: 2 residues, -Jump to DDX17_HUMAN  
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Loci Cluster (Details)Loci: 3313 36334448-36359516 ~-25K 24689(GGA1)(+)Loci: 3314 36365427-36392885 ~-27K 24693(+)Loci: 3315 36533890-36543129 ~-9K 24705(GCAT)(+)Loci: 3316 36549334-36551448 ~-2K 24707(GALR3)(+)Loci: 3317 36783348-36801653 ~-18K 24722(PRKCABP)(+)Loci: 4568 36810855-36836622 ~-26K 24725(-)Loci: 4569 37152280-37181149 ~-29K 24733(KCNJ4)(-)Loci: 4570 37209390-37232262 ~-23K 24737(DDX17)(-)Loci: 4571 37460680-37481928 ~-21K 24750(UNC84B)(-)Loci: 4567 35932191-35938299 ~-6K 24676(SSTR3)(-)Link out to UCSC