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0DDR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDDR1
DescriptionEpithelial discoidin domain receptor 1 precursor (ec 2.7.1.112) (tyrosine kinase ddr) (discoidin receptor tyrosine kinase) (tyrosine- protein kinase cak) (cell adhesion kinase) (trk e) (protein-tyrosine kinase rtk 6) (cd167a antigen) (hgk2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004714 transmembrane receptor protein tyrosine kin... (TAS)
0007155 cell adhesion (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Protein kinases comprise a large family of enzymes that mediate the response of eukaryotic cells to external stimuli by phosphorylation of hydroxyamino acids. The enzymes fall into two broad classes.haracterised with respect to substrate specificity: serine/threonine specific and tyrosine specific . Tyrosine phosphorylating activity was originally detected in two viral transforming proteins .ut many retroviral transforming proteins and their cellular counterparts have since been shown to possess such activity. The growth factor receptors.hich are activated by ligand binding.nd theinsulin-related peptide receptor.re also family members.
  IPR001245:Tyrosine protein kinase
Blood coagulation factors V and VIII contain a C-terminal.wice repeated.omain of about 150 amino acids.hich is called F5/8 type C.A58C.r C1/C2-like domain. In the slime mold cell adhesion protein discoidin. relateddomain.amed discoidin I-like domain.LD.r DS.as been found which sharesa common C-terminal region of about 110 amino acids with the FA58C domain.utwhose N-terminal 40 amino acids are much less conserved. Similar domains havebeen detected in other extracellular and membrane proteins In coagulation factors V and VIII the repeated domains compose part of alarger functional domain which promotes binding to anionic phospholipids onthe surface of platelets and endothelial cells . The C-terminal domain ofthe second FA58C repeat (C2) of coagulation factor VIII has been shown to beresponsible for phosphatidylserine-binding and essential for activity .It forms an amphipathic alpha-helix.hich binds to the membrane .FA58C contains two conserved cysteines in most proteins.hich link theextremities of the domain by a disulphide bond . A further disulphidebond is located near the C-terminal of the second FA58C domain in MFGM .
  IPR000421:Coagulation factor 5/8 type, C-terminal
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Proteins containing a galactose-binding domain-like fold can be found in several different protein families.n both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands.uch as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase .hospholipids on the outer side of the mammalian cell membrane for coagulation factor Va .embrane-anchored ephrin for the Eph family of receptor tyrosine kinases .nd a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 . The structure of the galactose-binding domain-like members consists of a beta-sandwich.n which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members.espite an often low level of sequence similarity.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008979:Galactose-binding like
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR001245:TyrKc 
Evalue:-128 
Location:610-905IPR000421:FA58C 
Evalue:-33.4089353929735 
Location:30-185IPR000719:PROTEIN_KINASE_ATP 
Evalue:0 
Location:0-0
SequencesProtein: DDR1_HUMAN (913 aa)
mRNA: NM_013993 NM_013994
Local Annotation
Synapse Ontology
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK05124
  Level 3 annotation:
    discoidin domain receptor family, member 1
  Level 2 annotation:
    Cytokine receptors
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 2300931-2301092Exon2: 20 residues, 2302006-2302062Exon3: 44 residues, 2305069-2305196Exon4: 36 residues, 2305289-2305392Exon5: 78 residues, 2305583-2305812Exon6: 51 residues, 2307354-2307502Exon7: 35 residues, 2307761-2307861Exon8: 64 residues, 2308385-2308572Exon9: 84 residues, 2308679-2308926Exon10: 34 residues, 2309451-2309547Exon11: 52 residues, 2309655-2309807Exon12: 57 residues, 2310889-2311055Exon13: 39 residues, 2311787-2311898Exon14: 83 residues, 2313004-2313249Exon15: 44 residues, 2313397-2313525Exon16: 75 residues, 2313762-2313981Exon17: 80 residues, 2314456-2314691Exon18: 52 residues, 2315271-2315421Exon19: 335 residues, 2315539-2316538Exon20: 2 residues, -Jump to DDR1_HUMANExon1: 43 residues, 2305069-2305196Exon2: 36 residues, 2305289-2305392Exon3: 78 residues, 2305583-2305812Exon4: 51 residues, 2307354-2307502Exon5: 35 residues, 2307761-2307861Exon6: 64 residues, 2308385-2308572Exon7: 84 residues, 2308679-2308926Exon8: 34 residues, 2309451-2309547Exon9: 52 residues, 2309655-2309807Exon10: 57 residues, 2310889-2311055Exon11: 39 residues, 2311787-2311898Exon12: 83 residues, 2313004-2313249Exon13: 44 residues, 2313397-2313525Exon14: 81 residues, 2313744-2313981Exon15: 80 residues, 2314456-2314691Exon16: 52 residues, 2315271-2315421Exon17: 335 residues, 2315539-2316538Exon18: 2 residues, -Jump to DDR1_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 2099260-2099421Exon2: 20 residues, 2100335-2100391Exon3: 44 residues, 2103398-2103525Exon4: 36 residues, 2103618-2103721Exon5: 78 residues, 2103912-2104141Exon6: 51 residues, 2105683-2105831Exon7: 35 residues, 2106090-2106190Exon8: 64 residues, 2106714-2106901Exon9: 84 residues, 2107008-2107255Exon10: 34 residues, 2107780-2107876Exon11: 52 residues, 2107984-2108136Exon12: 57 residues, 2109218-2109384Exon13: 39 residues, 2110116-2110227Exon14: 83 residues, 2111333-2111578Exon15: 44 residues, 2111726-2111854Exon16: 75 residues, 2112091-2112310Exon17: 80 residues, 2112785-2113020Exon18: 52 residues, 2113600-2113750Exon19: 335 residues, 2113868-2114867Exon20: 2 residues, -Jump to DDR1_HUMANExon1: 43 residues, 2103398-2103525Exon2: 36 residues, 2103618-2103721Exon3: 78 residues, 2103912-2104141Exon4: 51 residues, 2105683-2105831Exon5: 35 residues, 2106090-2106190Exon6: 64 residues, 2106714-2106901Exon7: 84 residues, 2107008-2107255Exon8: 34 residues, 2107780-2107876Exon9: 52 residues, 2107984-2108136Exon10: 57 residues, 2109218-2109384Exon11: 39 residues, 2110116-2110227Exon12: 83 residues, 2111333-2111578Exon13: 44 residues, 2111726-2111854Exon14: 81 residues, 2112073-2112310Exon15: 80 residues, 2112785-2113020Exon16: 52 residues, 2113600-2113750Exon17: 335 residues, 2113868-2114867Exon18: 2 residues, -Jump to DDR1_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 30960305-30960466Exon2: 20 residues, 30961380-30961436Exon3: 44 residues, 30964443-30964570Exon4: 36 residues, 30964663-30964766Exon5: 78 residues, 30964957-30965186Exon6: 51 residues, 30966728-30966876Exon7: 35 residues, 30967135-30967235Exon8: 64 residues, 30967757-30967944Exon9: 84 residues, 30968051-30968298Exon10: 34 residues, 30968823-30968919Exon11: 52 residues, 30969027-30969179Exon12: 57 residues, 30970261-30970427Exon13: 39 residues, 30971159-30971270Exon14: 83 residues, 30972376-30972621Exon15: 44 residues, 30972769-30972897Exon16: 75 residues, 30973134-30973353Exon17: 80 residues, 30973828-30974063Exon18: 52 residues, 30974643-30974793Exon19: 335 residues, 30974911-30975910Exon20: 2 residues, -Jump to DDR1_HUMANExon1: 43 residues, 30964443-30964570Exon2: 36 residues, 30964663-30964766Exon3: 78 residues, 30964957-30965186Exon4: 51 residues, 30966728-30966876Exon5: 35 residues, 30967135-30967235Exon6: 64 residues, 30967757-30967944Exon7: 84 residues, 30968051-30968298Exon8: 34 residues, 30968823-30968919Exon9: 52 residues, 30969027-30969179Exon10: 57 residues, 30970261-30970427Exon11: 39 residues, 30971159-30971270Exon12: 83 residues, 30972376-30972621Exon13: 44 residues, 30972769-30972897Exon14: 81 residues, 30973116-30973353Exon15: 80 residues, 30973828-30974063Exon16: 52 residues, 30974643-30974793Exon17: 335 residues, 30974911-30975910Exon18: 2 residues, -Jump to DDR1_HUMAN  
Loci Cluster (Details)Loci: 3568 1080116-1095456 ~-15K 32266(MOG)(+)Loci: 4846 1569907-1577353 ~-7K 32295(TRIM10)(-)Loci: 3569 1743552-1760022 ~-16K 32299(+)Loci: 4847 2116160-2131531 ~-15K 32327(MDC1)(-)Loci: 3570 2136731-2141768 ~-5K 32330(TUBB2)(+)Loci: 3571 2300931-2316538 ~-16K 32336(DDR1)(+)Loci: 4848 2583391-2589717 ~-6K 32358(POU5F1)(-)Loci: 3572 2942907-2944177 ~-1K 32370(MCCD1)(+)Loci: 3573 2989472-2992233 ~-3K 32379(TNF)(+)Loci: 3574 3034720-3051660 ~-17K 32394(BAT2)(+)Loci: 4849 3100861-3117213 ~-16K 32408(BAT5)(-)Loci: 4850 3144482-3150469 ~-6K 32420(CLIC1)(-)Loci: 4851 3273206-3276937 ~-4K 32436(NEU1)(-)Loci: 4852 3366127-3373127 ~-7K 32450(RDBP)(-)Loci: 4853 3416089-3484322 ~-68K 32465(TNXB)(-)Loci: 4854 3490215-3503197 ~-13K 32467(CREBL1)(-)Loci: 4855 3569805-3599027 ~-29K 32497(NOTCH4)(-)Loci: 4845 1025321-1056177 ~-31K 32256(GABBR1)(-)Link out to UCSC  
Loci: 3576 882132-897414 ~-15K 32584(MOG)(+)Loci: 4860 1368158-1375605 ~-7K 32610(TRIM10)(-)Loci: 3577 1541880-1558353 ~-16K 32616(+)Loci: 4861 1914463-1929833 ~-15K 32644(MDC1)(-)Loci: 3578 1935034-1940072 ~-5K 32647(TUBB2)(+)Loci: 3579 2099260-2114867 ~-16K 32653(DDR1)(+)Loci: 4862 2381927-2388269 ~-6K 32673(POU5F1)(-)Loci: 3580 2744366-2745636 ~-1K 32685(MCCD1)(+)Loci: 3581 2790934-2793697 ~-3K 32694(TNF)(+)Loci: 3582 2836184-2853121 ~-17K 32708(BAT2)(+)Loci: 4863 2902325-2918686 ~-16K 32722(BAT5)(-)Loci: 4864 2945936-2951926 ~-6K 32734(CLIC1)(-)Loci: 4865 3074690-3078421 ~-4K 32743(NEU1)(-)Loci: 4866 3167604-3174600 ~-7K 32757(RDBP)(-)Loci: 4867 3377585-3406812 ~-29K 32798(NOTCH4)(-)Loci: 4859 827283-858139 ~-31K 32580(GABBR1)(-)Link out to UCSC  
Loci: 3524 30403018-30419484 ~-16K 30623(+)Loci: 4778 30775563-30790934 ~-15K 30651(MDC1)(-)Loci: 3525 30796135-30801172 ~-5K 30654(TUBB2)(+)Loci: 3526 30960305-30975910 ~-16K 30660(DDR1)(+)Loci: 4779 31240107-31246432 ~-6K 30683(POU5F1)(-)Loci: 3527 31651328-31654089 ~-3K 30704(TNF)(+)Loci: 3528 31696575-31713516 ~-17K 30718(BAT2)(+)Loci: 4780 31762714-31779067 ~-16K 30732(BAT5)(-)Loci: 4781 31806338-31812320 ~-6K 30744(CLIC1)(-)Loci: 4782 31934931-31938662 ~-4K 30760(NEU1)(-)Loci: 4783 32027843-32034843 ~-7K 30774(RDBP)(-)Loci: 4784 32116910-32185131 ~-68K 30791(TNXB)(-)Loci: 4785 32191022-32204008 ~-13K 30793(CREBL1)(-)Loci: 4786 32270598-32299822 ~-29K 30822(NOTCH4)(-)Loci: 4777 30229242-30236690 ~-7K 30617(TRIM10)(-)Link out to UCSC