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0DCTN2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDCTN2
DescriptionDynactin subunit 2 (dynactin complex 50 kda subunit) (50 kda dynein- associated polypeptide) (p50 dynamitin) (dctn-50).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005813 centrosome (TAS)
0005869 dynactin complex (TAS)
0000776 kinetochore (TAS)
0008283 cell proliferation (TAS)
0007067 mitosis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Dynamitin is a subunit of the microtubule-dependent motor complex.t is also implicated in cell adhesion by binding to macrophage-enriched myristoylated alanine-rice C kinase substrate (MacMARCKS) .
  IPR006996:Dynamitin
Signal transducing histidine kinases are the key elements in two-component signal transduction systems.hich control complex processes such as the initiation of development in microorganisms . Examples of histidine kinases are EnvZ.hich plays a central role in osmoregulation .nd CheA.hich plays a central role in the chemotaxis system . Histidine kinases usually have an N-terminal ligand-binding domain and a C-terminal kinase domain.ut other domains may also be present. The kinase domain is responsible for the autophosphorylation of the histidine with ATP.he phosphotransfer from the kinase to an aspartate of the response regulator.nd the phosphotransfer from aspartyl phosphate back to ADP or to water . The homodimeric domain includes the site of histidine autophosphorylation and phosphate transfer reactions. The structure of the homodimeric domain comprises a closed.our-helical bundle with a left-handed twist.ormed by two identical alpha-hairpin subunits.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009082:Histidine kinase, homodimeric
IPR006996:Dynamitin 
Evalue:-269.698974609375 
Location:10-399
SequencesProtein: DCTN2_HUMAN (400 aa)
mRNA: BC000718
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 156 residues, 56210360-56210825Exon2: 32 residues, 56212064-56212156Exon3: 36 residues, 56212262-56212365Exon4: 26 residues, 56212621-56212693Exon5: 28 residues, 56212782-56212860Exon6: 15 residues, 56213033-56213072Exon7: 24 residues, 56213287-56213353Exon8: 50 residues, 56214002-56214147Exon9: 55 residues, 56214341-56214502Exon10: 35 residues, 56215105-56215204Exon11: 22 residues, 56215533-56215595Exon12: 34 residues, 56215798-56215895Exon13: 25 residues, 56226077-56226146Exon14: 58 residues, 56227077-56227245Exon15: 2 residues, -Jump to DCTN2_HUMAN  
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Loci Cluster (Details)Loci: 2768 56462825-56476784 ~-14K 9198(TSFM)(+)Loci: 4058 56477709-56496119 ~-18K 9200(AVIL)(-)Loci: 4057 56210360-56227245 ~-17K 9162(DCTN2)(-)Link out to UCSC