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0DCPS_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDCPS
DescriptionScavenger mrna decapping enzyme dcps (ec 3.-.-.-) (dcs-1) (hint- related 7megmp-directed hydrolase) (histidine triad protein member 5) (hint-5).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of several scavenger mRNA decapping enzymes (DcpS). DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3 to 5 decay of an mRNA. The association of DcpS with 3 to 5 exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain.aking DcpS the first member of the HIT family of proteins with a defined biological function. This family is related to
  IPR008594:Scavenger mRNA decapping enzyme
IPR008594:DcpS 
Evalue:-242.494842529297 
Location:25-337
SequencesProtein: DCPS_HUMAN (337 aa)
mRNA: NM_014026
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01567
  Level 3 annotation:
    
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 177 residues, 125678856-125679386Exon2: 60 residues, 125681674-125681849Exon3: 50 residues, 125706509-125706655Exon4: 40 residues, 125713390-125713504Exon5: 39 residues, 125718411-125718522Exon6: 136 residues, 125720451-125720853Exon7: 2 residues, -Jump to DCPS_HUMAN  
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