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0DCE1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGAD1
DescriptionGlutamate decarboxylase 1 (ec 4.1.1.15) (glutamate decarboxylase, 67 kda isoform) (gad-67) (67 kda glutamic acid decarboxylase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005622 intracellular (IDA)
0012506 vesicle membrane (NAS)
0004351 glutamate decarboxylase activity (IDA)
0005515 protein binding (IPI)
0006540 glutamate decarboxylation to succinate (TAS)
0018352 protein-pyridoxal-5-phosphate linkage (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of pyridoxal-dependent decarboxylases share regions of sequence similarity.articularly in the vicinity of a conserved lysine residue.hich provides the attachment site for the pyridoxal-phosphate (PLP) group . Among these enzymes are aromatic-L-amino-acid decarboxylase (L-dopa decarboxylase or tryptophan decarboxylase).hich catalyses the decarboxylation of tryptophan to tryptamine ; tyrosine decarboxylase.hich converts tyrosine into tyramine; and histidine decarboxylase.hich catalyses the decarboxylation of histidine to histamine . These enzymes belong to the group II decarboxylases .
  IPR002129:Pyridoxal-dependent decarboxylase
IPR002129:Pyridoxal_deC 
Evalue:-210.920822143555 
Location:144-518
SequencesProtein: DCE1_HUMAN (594 aa)
mRNA: BC036552 NM_000817
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK01580
  Level 3 annotation:
    glutamate decarboxylase
  Level 2 annotation:
    Butanoate metabolism
    Glutamate metabolism
    Alanine and aspartate metabolism
    beta-Alanine metabolism
    Taurine and hypotaurine metabolism
    Type I diabetes mellitus
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 120 residues, 171381445-171381804Exon2: 50 residues, 171383284-171383429Exon3: 23 residues, 171386842-171386905Exon4: 55 residues, 171394230-171394389Exon5: 83 residues, 171395705-171395948Exon6: 32 residues, 171401548-171401639Exon7: 39 residues, 171408800-171408913Exon8: 40 residues, 171410261-171410377Exon9: 28 residues, 171410461-171410541Exon10: 20 residues, 171410764-171410819Exon11: 41 residues, 171412431-171412548Exon12: 23 residues, 171414041-171414106Exon13: 28 residues, 171417469-171417548Exon14: 52 residues, 171418628-171418778Exon15: 38 residues, 171421773-171421881Exon16: 32 residues, 171423559-171423649Exon17: 481 residues, 171424464-171425903Exon18: 2 residues, -Jump to DCE1_HUMANExon1: 302 residues, 171382525-171383429Exon2: 23 residues, 171386842-171386905Exon3: 55 residues, 171394230-171394389Exon4: 83 residues, 171395705-171395948Exon5: 32 residues, 171401548-171401639Exon6: 39 residues, 171408800-171408913Exon7: 40 residues, 171410261-171410377Exon8: 28 residues, 171410461-171410541Exon9: 20 residues, 171410764-171410819Exon10: 41 residues, 171412431-171412548Exon11: 39 residues, 171413438-171413550Exon12: 23 residues, 171414041-171414106Exon13: 28 residues, 171417469-171417548Exon14: 52 residues, 171418628-171418778Exon15: 38 residues, 171421773-171421881Exon16: 32 residues, 171423559-171423649Exon17: 481 residues, 171424464-171425903Exon18: 2 residues, -Jump to DCE1_HUMAN  
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