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0DCAK2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDCAMKL2
DescriptionSerine/threonine-protein kinase dcamkl2 (ec 2.7.1.37) (doublecortin- like and cam kinase-like 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
X-linked lissencephaly is a severe brain malformation affecting males.Recently it has been demonstrated that the doublecortin gene is implicated inthis disorder . Doublecortin was found to bind to the microtubulecytoskeleton. In vivo and in vitro assays show that Doublecortin stabilizesmicrotubules and causes bundling . Doublecortin is a basic protein with aniso-electric point of 10.ypical of microtubule-binding proteins. However.ts sequence contains no known microtubule-binding domain(s). The detailed sequence analysis of Doublecortin and Doublecortin-like proteinsallowed the identification of an evolutionarily conserved Doublecortin (DC)domain. This domain is found in the N-terminus of proteins and consists of oneor two tandemly repeated copies of an around 80 amino acids region. It hasbeen suggested that the first DC domain of Doublecortin binds tubulin andenhances microtubule polymerization .
  IPR003533:Doublecortin
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-100.318758762624 
Location:394-651IPR003533:DCX 
Evalue:-41.698970004336 
Location:67-158IPR003533:DCX 
Evalue:-35.6777807052661 
Location:192-280
SequencesProtein: DCAK2_HUMAN (766 aa)
mRNA: AB209181 NM_152619
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK00870
  Level 3 annotation:
    protein kinase
  Level 2 annotation:
    Signal transduction mechanisms
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 392 residues, 151218875-151220050Exon2: 113 residues, 151243079-151243414Exon3: 36 residues, 151333739-151333842Exon4: 36 residues, 151338603-151338705Exon5: 33 residues, 151344396-151344491Exon6: 27 residues, 151361304-151361380Exon7: 38 residues, 151362278-151362387Exon8: 21 residues, 151365102-151365160Exon9: 42 residues, 151372938-151373058Exon10: 51 residues, 151373283-151373430Exon11: 46 residues, 151380343-151380477Exon12: 28 residues, 151381000-151381078Exon13: 34 residues, 151388204-151388301Exon14: 29 residues, 151388906-151388987Exon15: 41 residues, 151390169-151390286Exon16: 472 residues, 151396621-151398033Exon17: 2 residues, -Jump to DCAK2_HUMANExon1: 154 residues, 151219590-151220050Exon2: 113 residues, 151243079-151243414Exon3: 36 residues, 151333739-151333842Exon4: 36 residues, 151338603-151338705Exon5: 33 residues, 151344396-151344491Exon6: 26 residues, 151361307-151361380Exon7: 38 residues, 151362278-151362387Exon8: 21 residues, 151365102-151365160Exon9: 42 residues, 151372938-151373058Exon10: 51 residues, 151373283-151373430Exon11: 46 residues, 151380343-151380477Exon12: 28 residues, 151381000-151381078Exon13: 34 residues, 151388204-151388301Exon14: 29 residues, 151388906-151388987Exon15: 41 residues, 151390169-151390286Exon16: 29 residues, 151394075-151394158Exon17: 472 residues, 151396621-151398033Exon18: 2 residues, -Jump to DCAK2_HUMAN  
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