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0DBLOH_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDIABLO
DescriptionDiablo homolog, mitochondrial precursor (second mitochondria-derived activator of caspase) (smac protein) (direct iap binding protein with low pi).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0005515 protein binding (IPI)
0008635 caspase activation via cytochrome c (TAS)
0006917 induction of apoptosis (TAS)
0008625 induction of apoptosis via death domain rec... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Apoptosis.r programmed cell death.s an essential process in metazoan development and homeostasis. Apoptosis is carried out by caspases.hich are under tight regulatory control. Inhibitor-of-apoptosis proteins (IAP) suppress apoptosis by inhibiting caspases.hile the mitochondrial protein Smac/Diablo promotes apoptosis by suppressing IAPs. The N-terminal four sequences in Smac/Diablo are responsible for the proteins interaction with IAPs . The crystal structure of Smac/Diablo reveals a closed.hree-helical bundle structure with a left-handed twist.nd that the protein homodimerises through an extensive hydrophobic interface .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009062:Smac/Diablo
IPR009062:Smac_Diablo 
Evalue:0 
Location:56-212
SequencesProtein: DBLOH_HUMAN (239 aa)
mRNA: NM_019887
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 306 residues, 121258162-121259077Exon2: 34 residues, 121266987-121267084Exon3: 39 residues, 121267258-121267369Exon4: 46 residues, 121268765-121268897Exon5: 46 residues, 121275011-121275144Exon6: 31 residues, 121276464-121276552Exon7: 2 residues, -Jump to DBLOH_HUMAN  
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Loci Cluster (Details)Loci: 4084 121282046-121316970 ~-35K 9906(VPS33A)(-)Loci: 2797 121577761-121676899 ~-99K 9919(KNTC1)(+)Loci: 2798 121885991-121913460 ~-27K 9929(HIP1R)(+)Loci: 4083 121258162-121276552 ~-18K 9902(DIABLO)(-)Link out to UCSC