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0CY561_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCYB561
DescriptionCytochrome b561 (cytochrome b-561).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004128 cytochrome-b5 reductase activity (TAS)
0006091 generation of precursor metabolites and energy (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein.hat binds two heme groups non-covalently.
  IPR004877:Cytochrome b561
Cytochromes b561 constitute a class of intrinsic membrane proteins containing two heme molecules that are involved in ascorbate (vitamin C) regeneration. They have been suggested to function as electron transporters.huttling electrons across membranes from ascorbate to an acceptor molecule. The one-electron oxidation product of ascorbate.onodehydro-ascorbate (MDHA) has been shown to function as an electon acceptor for mammalian and plant cytochromes b561. The cytochrome b561-catalyzed reduction of MDHA results in the regeneration of the fully reduced ascorbate molecule. Cytochromes b561 have been identified in a large number of phylogenetically distant species.ut are absent in prokaryotes. Most species contain three or four cytochrome b561 paralogous proteins .Members of the cytochrome b561 protein family are characterized by a number of structural features.ikely to play an essential part in their function. They are highly hydrophobic proteins with six transmembrane helices (named TMH1 through TMH6).our conserved histidine residues.robably coordinating the two heme molecules.nd predicted substrate-binding sites for ascorbate and MDHA . The functionally relevant and structurally most conserved region in the cytochrome b561 family is the TMH2 to -5 4-helix core with an amino acid composition that is very well conserved in the inner surface and somewhat less conserved in the outer surface of the core. The two terminal helices (TMH1 and TMH6) are less conserved .The entry represents a conserved region containing six transmembrane helices.ound in cytochrome b651 and homologous proteins including some ferric reductases.
  IPR006593:Cytochrome b561 / ferric reductase transmembrane
IPR004877:Cytochrom_B561 
Evalue:-100.455932617187 
Location:17-231
SequencesProtein: CY561_HUMAN (251 aa)
mRNA: NM_001017916
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 764 residues, 58863397-58865687Exon2: 54 residues, 58866178-58866336Exon3: 36 residues, 58866780-58866884Exon4: 35 residues, 58867146-58867245Exon5: 73 residues, 58868438-58868653Exon6: 97 residues, 58876990-58877277Exon7: 2 residues, -Jump to CY561_HUMAN  
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Loci Cluster (Details)Loci: 3027 58954426-58977332 ~-23K 16390(KCNH6)(+)Loci: 4309 59369645-59404010 ~-34K 16427(SCN4A)(-)Loci: 4308 58863397-58877277 ~-14K 16385(CYB561)(-)Link out to UCSC