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0CXCR4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCXCR4
DescriptionC-x-c chemokine receptor type 4 (cxc-r4) (cxcr-4) (stromal cell- derived factor 1 receptor) (sdf-1 receptor) (fusin) (leukocyte-derived seven transmembrane domain receptor) (lestr) (lcr1) (fb22) (npyrl) (hm89) (cd184 antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016494 C-X-C chemokine receptor activity (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Chemokines are proteins that have important physiological and pathophysiological roles in a wide range of acute and chronic inflammatoryprocesses. Their sequences are similar and are characterised by a4-cysteine motif: the family can be divided according to whether thefirst 2 Cys residues are adjacent (the C-C family).r separated by anintervening residue (the C-x-C family). C-C chemokines are chemoattractantfor monocytes but not for neutrophils. The C-C family includes humanmonocyte chemotactic protein-1 (MCP-1).egulated on activation.ormalT cell expressed and secreted (RANTES) and macrophage inflammatory proteins(MIP-1a and MIP-1b) .C-C chemokine receptors are found in monocytes.ymphocytes.asophils andeosinophils; mRNA is also found in some cell lines. MCP-1 and MIP-1ainduce activation in low nanomolar concentrations and are highly selectiverelative to C-x-C receptors. Calcium mobilisation has been demonstrated inmonocytes and in cells expressing the recombinant C-C receptor via anuncharacterised G-protein; pertussis toxin inhibits some of its actions .
  IPR000355:Chemokine receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Chemokines are proteins that have important physiological and patho- physiological roles in a wide range of acute and chronic inflammatory processes . Their sequences are similar and are characterised by a 4-cysteine motif: the family can be divided according to whether the first 2Cys residues are adjacent (the C-C family).r separated by an interveningresidue (the C-x-C family).Several 7TM receptors have been cloned but their endogenous ligands areunknown; these have been termed orphan receptors. LCR1 was isolated from a locus coeruleus library and its mRNA is also present in cerebellum.ons.orsal raphe.halamus and substantia nigra . It was originally thought to encode a neuropeptide Y receptor (NPY3-R) .ut this has been shown to be incorrect .nd it is now thought to be a type 4 C-X-C chemokine receptor.
  IPR001277:C-X-C chemokine receptor, type 4
IPR000276:7tm_1 
Evalue:-89.2441253662109 
Location:55-302IPR000355:CCCHEMOKINER 
Evalue:0 
Location:28-46IPR001277:CXCCHMKINER4 
Evalue:0 
Location:322-340IPR000355:CCCHEMOKINER 
Evalue:0 
Location:304-318IPR003006:IG_MHC 
Evalue:0 
Location:0-0
SequencesProtein: CXCR4_HUMAN (352 aa)
mRNA: NM_003467
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentK04189
  Level 3 annotation:
    chemokine (C-X-C motif) receptor 4
  Level 2 annotation:
    G-protein coupled receptors
    Cytokine receptors
    Cytokine-cytokine receptor interaction
    CD molecules
    Leukocyte transendothelial migration
    Axon guidance
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 522 residues, 136588389-136589952Exon2: 38 residues, 136592085-136592195Exon3: 2 residues, -Jump to CXCR4_HUMAN  
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