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0CTCF_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionTranscriptional repressor ctcf (ccctc-binding factor) (ctcfl paralog) (11-zinc finger protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (IDA)
0003702 RNA polymerase II transcription factor acti... (TAS)
0003714 transcription corepressor activity (TAS)
0003700 transcription factor activity (IDA)
0008270 zinc ion binding (TAS)
0000122 negative regulation of transcription from R... (TAS)
0045893 positive regulation of transcription, DNA-d... (IDA)
0000074 regulation of progression through cell cycle (IDA)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
SequencesProtein: CTCF_HUMAN (727 aa)
mRNA: NM_006565
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 55 residues, 66153964-66154128Exon2: 41 residues, 66162551-66162668Exon3: 265 residues, 66202227-66203017Exon4: 59 residues, 66203354-66203525Exon5: 46 residues, 66208148-66208282Exon6: 42 residues, 66212100-66212221Exon7: 52 residues, 66212845-66212995Exon8: 55 residues, 66217958-66218119Exon9: 63 residues, 66219773-66219956Exon10: 47 residues, 66220801-66220937Exon11: 56 residues, 66228093-66228255Exon12: 501 residues, 66229091-66230588Exon13: 2 residues, -Jump to CTCF_HUMAN  
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Loci Cluster (Details)Loci: 2945 65471936-65479356 ~-7K 14263(PDP2)(+)Loci: 4230 65513089-65516920 ~-4K 14266(RRAD)(-)Loci: 4231 65767007-65774977 ~-8K 14287(-)Loci: 2946 66153964-66230588 ~-77K 14315(CTCF)(+)Loci: 2947 66252351-66254181 ~-2K 14321(PARD6A)(+)Loci: 4232 66531287-66535516 ~-4K 14345(LCAT)(-)Loci: 4233 66535730-66560026 ~-24K 14346(SLC12A4)(-)Loci: 4229 65102150-65141816 ~-40K 14239(TK2)(-)Link out to UCSC