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0CSPG5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCSPG5
DescriptionChondroitin sulfate proteoglycan 5 precursor (neuroglycan c) (acidic leucine-rich egf-like domain containing brain protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
This family represents the chondroitin sulphate attachment domain of vertebrate neural transmembrane proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis.ifferentiation.xonal outgrowth and synaptogenesis . This domain contains several potential sites of chondroitin sulphate attachment.s well as potential sites of N-linked glycosylation .
  IPR010555:Chondroitin sulphate attachment
This entry represents the C-terminal cytoplasmic domain of vertebrate neural chondroitin sulphate proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis.ifferentiation.xonal outgrowth and synaptogenesis . This domain contains a number of potential sites of phosphorylation by protein kinase C .
  IPR009505:Neural chondroitin sulphate proteoglycan cytoplasmic
InterPro domains unassigned to SynO:
Epidermal growth factors and transforming growth factors belong to a general class of proteins that share a repeat pattern involving a number of conserved Cys residues. Growth factors are involved in cell recognition and division . The repeating pattern.specially of cysteines (the so-called EGF repeat).s thought to be important to the 3D structure of the proteins.nd hence its recognition by receptors and other molecules. The type 1 EGF signature includes six conserved cysteines believed to be involved in disulphide bond formation. The EGF motif is found frequently in nature.articularly in extracellular proteins.
  IPR006210:EGF
IPR010555:Chon_Sulph_att 
Evalue:-168.376754760742 
Location:31-277IPR009505:Neural_ProG_Cyt 
Evalue:-87.1023712158203 
Location:447-566IPR000742:EGF_3 
Evalue:0 
Location:0-0IPR006210:EGF 
Evalue:1.30102999566398 
Location:373-413
SequencesProtein: CSPG5_HUMAN (566 aa)
mRNA: NM_006574
Local Annotation
Synapse Ontology
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:domains)
KO assignmentK08116
  Level 3 annotation:
    chondroitin sulfate proteoglycan 5 (neuroglycan C)
  Level 2 annotation:
    Proteoglycans
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 175 residues, 47578732-47579255Exon2: 54 residues, 47585564-47585721Exon3: 65 residues, 47589179-47589368Exon4: 367 residues, 47593326-47594422Exon5: 734 residues, 47595090-47597286Exon6: 2 residues, -Jump to CSPG5_HUMANExon1: 175 residues, 47578732-47579255Exon2: 27 residues, 47585645-47585721Exon3: 65 residues, 47589179-47589368Exon4: 367 residues, 47593326-47594422Exon5: 36 residues, 47595090-47595193Exon6: 2 residues, -Jump to CSPG5_HUMAN  
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