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0CSN7A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionCop9 signalosome complex subunit 7a (signalosome subunit 7a) (sgn7a) (jab1-containing signalosome subunit 7a) (dermal papilla derived protein 10).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A homology domain of unclear function.ccurs in the C-terminal region of severalregulatory components of the 26S proteasome as well as in other proteins. This domainhas also been called the PINT motif (Proteasome.nt-6.ip-1 and TRIP-15) .Apparently.ll of the characterized proteins containing PCI domains are parts of largermulti-protein complexes. Proteins with PCI domains include budding yeast proteasomeregulatory components Rpn3(Sun2).pn5.pn6.pn7and Rpn9 ; mammalian proteasome regulatory components p55.58 and p44.5.nd translationinitiation factor 3 complex subunits p110 and INT6 . ArabidopsisCOP9 and FUS6/COP11 ; mammalian G-protein pathway suppressor GPS1.nd severaluncharacterized ORFs from plant.ematodes and mammals. The complete homology domain comprisesapprox. 200 residues.he highest conservation is found in the C-terminal half. Several of theproteins mentioned above have no detectable homology to the N-terminal half of the domain.
  IPR000717:Proteasome component region PCI
SequencesProtein: CSN7A_HUMAN (275 aa)
mRNA: NM_016319
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 33 residues, 6703481-6703579Exon2: 70 residues, 6704040-6704245Exon3: 27 residues, 6707352-6707428Exon4: 31 residues, 6707649-6707738Exon5: 69 residues, 6708673-6708876Exon6: 37 residues, 6709828-6709934Exon7: 52 residues, 6710095-6710247Exon8: 289 residues, 6710426-6711289Exon9: 2 residues, -Jump to CSN7A_HUMAN  
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Loci Cluster (Details)Loci: 4009 6326275-6354976 ~-29K 8222(SCNN1A)(-)Loci: 2731 6424326-6431144 ~-7K 8225(TNFRSF7)(+)Loci: 4010 6441666-6450104 ~-8K 8228(VAMP1)(-)Loci: 4011 6518966-6535498 ~-17K 8239(-)Loci: 4012 6549509-6586812 ~-37K 8245(CHD4)(-)Loci: 4013 6598261-6615548 ~-17K 8247(GPR92)(-)Loci: 2732 6703481-6711289 ~-8K 8256(COPS7A)(+)Loci: 2733 6846966-6850253 ~-3K 8271(TPI1)(+)Loci: 2734 7174236-7201985 ~-28K 8292(CLSTN3)(+)Loci: 4008 5928407-6103946 ~-176K 8213(VWF)(-)Link out to UCSC