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0CSN4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCOPS4
DescriptionCop9 signalosome complex subunit 4 (signalosome subunit 4) (sgn4) (jab1-containing signalosome subunit 4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A homology domain of unclear function.ccurs in the C-terminal region of severalregulatory components of the 26S proteasome as well as in other proteins. This domainhas also been called the PINT motif (Proteasome.nt-6.ip-1 and TRIP-15) .Apparently.ll of the characterized proteins containing PCI domains are parts of largermulti-protein complexes. Proteins with PCI domains include budding yeast proteasomeregulatory components Rpn3(Sun2).pn5.pn6.pn7and Rpn9 ; mammalian proteasome regulatory components p55.58 and p44.5.nd translationinitiation factor 3 complex subunits p110 and INT6 . ArabidopsisCOP9 and FUS6/COP11 ; mammalian G-protein pathway suppressor GPS1.nd severaluncharacterized ORFs from plant.ematodes and mammals. The complete homology domain comprisesapprox. 200 residues.he highest conservation is found in the C-terminal half. Several of theproteins mentioned above have no detectable homology to the N-terminal half of the domain.
  IPR000717:Proteasome component region PCI
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the tetratricopeptide repeat (TPR) (found in kinesin light chains.NAP regulatory proteins.lathrin heavy chains and bacterial aspartyl-phosphate phosphatases).nd the pentatricopeptide repeat (PPR) (RNA-processing proteins). The TRP is likely to be an ancient repeat.ince it is found in eukaryotes.acteria and archaea.hereas the PPR repeat is found predominantly in higher plants. The superhelix formed from these repeats can bind ligands at a number of different regions.nd has the ability to acquire multiple functional roles .
  IPR011990:Tetratricopeptide-like helical
IPR000717:PCI 
Evalue:-24.3467884063721 
Location:264-363IPR011990:TPR-like_helical 
Evalue:0 
Location:78-210
SequencesProtein: CSN4_HUMAN (406 aa)
mRNA: CR609378 NM_016129
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 72 residues, 84175262-84175475Exon2: 28 residues, 84185802-84185882Exon3: 52 residues, 84189342-84189494Exon4: 36 residues, 84190057-84190161Exon5: 53 residues, 84197102-84197256Exon6: 52 residues, 84197434-84197585Exon7: 59 residues, 84203252-84203423Exon8: 40 residues, 84206614-84206730Exon9: 30 residues, 84208614-84208699Exon10: 175 residues, 84215473-84215994Exon11: 2 residues, -Jump to CSN4_HUMANExon1: 31 residues, 84175383-84175475Exon2: 28 residues, 84185802-84185882Exon3: 52 residues, 84189342-84189494Exon4: 36 residues, 84190057-84190161Exon5: 53 residues, 84197102-84197256Exon6: 52 residues, 84197434-84197585Exon7: 59 residues, 84203252-84203423Exon8: 34 residues, 84205236-84205332Exon9: 40 residues, 84206614-84206730Exon10: 30 residues, 84208614-84208699Exon11: 167 residues, 84215473-84215970Exon12: 2 residues, -Jump to CSN4_HUMAN  
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Loci Cluster (Details)Loci: 3419 84596195-84601900 ~-6K 27854(MRPS18C)(+)Loci: 3418 84175262-84215994 ~-41K 27843(COPS4)(+)Link out to UCSC