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0CSN1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGPS1
DescriptionCop9 signalosome complex subunit 1 (signalosome subunit 1) (sgn1) (jab1-containing signalosome subunit 1) (g protein pathway suppressor 1) (gps1 protein) (mfh protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005095 GTPase inhibitor activity (TAS)
0007049 cell cycle (TAS)
0000188 inactivation of MAPK activity (TAS)
0007254 JNK cascade (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A homology domain of unclear function.ccurs in the C-terminal region of severalregulatory components of the 26S proteasome as well as in other proteins. This domainhas also been called the PINT motif (Proteasome.nt-6.ip-1 and TRIP-15) .Apparently.ll of the characterized proteins containing PCI domains are parts of largermulti-protein complexes. Proteins with PCI domains include budding yeast proteasomeregulatory components Rpn3(Sun2).pn5.pn6.pn7and Rpn9 ; mammalian proteasome regulatory components p55.58 and p44.5.nd translationinitiation factor 3 complex subunits p110 and INT6 . ArabidopsisCOP9 and FUS6/COP11 ; mammalian G-protein pathway suppressor GPS1.nd severaluncharacterized ORFs from plant.ematodes and mammals. The complete homology domain comprisesapprox. 200 residues.he highest conservation is found in the C-terminal half. Several of theproteins mentioned above have no detectable homology to the N-terminal half of the domain.
  IPR000717:Proteasome component region PCI
IPR000717:PCI 
Evalue:-24.4202156066895 
Location:304-408
SequencesProtein: CSN1_HUMAN (471 aa)
mRNA: BC000155 BC064503 CR606254 NM_004127 NM_212492
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 27 residues, 77603051-77603129Exon2: 33 residues, 77604438-77604531Exon3: 62 residues, 77605032-77605214Exon4: 106 residues, 77605662-77605975Exon5: 28 residues, 77606062-77606140Exon6: 22 residues, 77606326-77606387Exon7: 30 residues, 77606904-77606990Exon8: 33 residues, 77607165-77607260Exon9: 37 residues, 77607450-77607556Exon10: 29 residues, 77607634-77607715Exon11: 48 residues, 77607793-77607931Exon12: 47 residues, 77608004-77608139Exon13: 141 residues, 77608217-77608635Exon14: 2 residues, -Jump to CSN1_HUMANExon1: 192 residues, 77603051-77603624Exon2: 33 residues, 77604438-77604531Exon3: 62 residues, 77605032-77605214Exon4: 102 residues, 77605674-77605975Exon5: 28 residues, 77606062-77606140Exon6: 22 residues, 77606326-77606387Exon7: 30 residues, 77606904-77606990Exon8: 33 residues, 77607165-77607260Exon9: 37 residues, 77607450-77607556Exon10: 29 residues, 77607634-77607715Exon11: 48 residues, 77607793-77607931Exon12: 47 residues, 77608004-77608139Exon13: 141 residues, 77608217-77608635Exon14: 2 residues, -Jump to CSN1_HUMANExon1: 25 residues, 77603057-77603129Exon2: 33 residues, 77604438-77604531Exon3: 62 residues, 77605032-77605214Exon4: 106 residues, 77605662-77605975Exon5: 28 residues, 77606062-77606140Exon6: 21 residues, 77606329-77606387Exon7: 30 residues, 77606904-77606990Exon8: 33 residues, 77607165-77607260Exon9: 37 residues, 77607450-77607556Exon10: 29 residues, 77607634-77607715Exon11: 48 residues, 77607793-77607931Exon12: 47 residues, 77608004-77608139Exon13: 131 residues, 77608217-77608605Exon14: 2 residues, -Jump to CSN1_HUMANExon1: 19 residues, 77603073-77603129Exon2: 33 residues, 77604438-77604531Exon3: 62 residues, 77605032-77605214Exon4: 106 residues, 77605662-77605975Exon5: 28 residues, 77606062-77606140Exon6: 22 residues, 77606326-77606387Exon7: 30 residues, 77606904-77606990Exon8: 33 residues, 77607165-77607260Exon9: 37 residues, 77607450-77607556Exon10: 29 residues, 77607634-77607715Exon11: 48 residues, 77607793-77607931Exon12: 47 residues, 77608004-77608139Exon13: 140 residues, 77608217-77608632Exon14: 2 residues, -Jump to CSN1_HUMANExon1: 168 residues, 77603122-77603624Exon2: 33 residues, 77604438-77604531Exon3: 62 residues, 77605032-77605214Exon4: 102 residues, 77605674-77605975Exon5: 28 residues, 77606062-77606140Exon6: 22 residues, 77606326-77606387Exon7: 30 residues, 77606904-77606990Exon8: 33 residues, 77607165-77607260Exon9: 37 residues, 77607450-77607556Exon10: 29 residues, 77607634-77607715Exon11: 48 residues, 77607793-77607931Exon12: 47 residues, 77608004-77608139Exon13: 141 residues, 77608217-77608635Exon14: 2 residues, -Jump to CSN1_HUMAN  
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Loci Cluster (Details)Loci: 4323 76816673-76827450 ~-11K 16811(-)Loci: 4324 77091593-77094422 ~-3K 16823(ACTG1)(-)Loci: 3047 77261424-77279550 ~-18K 16838(HGS)(+)Loci: 3048 77451912-77454066 ~-2K 16852(NPB)(+)Loci: 3049 77603051-77608635 ~-6K 16881(GPS1)(+)Loci: 4325 77629503-77649395 ~-20K 16888(FASN)(-)Loci: 4326 77795530-77824862 ~-29K 16893(CSNK1D)(-)Loci: 4327 78208237-78249802 ~-42K 16919(RAB40B)(-)Loci: 3046 76623556-76705827 ~-82K 16801(BAIAP2)(+)Link out to UCSC