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0CSK22_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCSNK2A2
DescriptionCasein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0004682 protein kinase CK2 activity (TAS)
0007165 signal transduction (TAS)
0007286 spermatid development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-94.1870880126953 
Location:40-325
SequencesProtein: CSK22_HUMAN (350 aa)
mRNA: NM_001896
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK03097
  Level 3 annotation:
    casein kinase 2, alpha polypeptide
  Level 2 annotation:
    Wnt signaling pathway
    Adherens junction
    Tight junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 148 residues, 56749316-56749758Exon2: 33 residues, 56755458-56755552Exon3: 51 residues, 56756964-56757113Exon4: 35 residues, 56757988-56758089Exon5: 36 residues, 56758611-56758713Exon6: 39 residues, 56759089-56759200Exon7: 30 residues, 56760014-56760098Exon8: 22 residues, 56765855-56765915Exon9: 19 residues, 56775664-56775715Exon10: 36 residues, 56778159-56778261Exon11: 39 residues, 56788137-56788249Exon12: 84 residues, 56789037-56789283Exon13: 2 residues, -Jump to CSK22_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2944 56327160-56348663 ~-22K 14187(KATNB1)(+)Loci: 4226 56349631-56393909 ~-44K 14188(KIFC3)(-)Loci: 4227 56749316-56789283 ~-40K 14207(CSNK2A2)(-)Loci: 4228 57112105-57221249 ~-109K 14223(-)Loci: 2943 55950218-55957600 ~-7K 14167(CCL22)(+)Link out to UCSC