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0CREM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCREM
Descriptioncamp responsive element modulator.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (NAS)
0003677 DNA binding (NAS)
0006355 regulation of transcription, DNA-dependent (NAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The basic-leucine zipper (bZIP) transcription factors .f eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region (see ) required for dimerization.
  IPR011616:bZIP transcription factor, bZIP_1
The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner. CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB .
  IPR003102:Coactivator CBP, pKID
The basic-leucine zipper (bZIP) transcription factors .f eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region (see ) required for dimerization.
  IPR004827:Basic-leucine zipper (bZIP) transcription factor
Transcription initiation is dictated by the presence and activity of specific nuclear factors that bind to DNA regulatory sequences and interact with the transcriptional machinery. The functions of some of these factors can be altered by phosphorylation.hich affects both DNA binding and transcriptional activation . Phosphorylation is effected by specific protein kinases that have been activated by the stimulus of signal transduction pathways.esulting in the regulation of gene transcription by modulating the phosphorylation sites of transcription factors.Cyclic AMP (cAMP) regulates the expression of many genes via a conserved gene promoter element CRE (cAMP response element) .hich has the sequence 5-TGACGTCA-3 . The cAMP response element binding protein (CREB) is a nuclear factor that is regulated by protein kinase A phosphorylation. Transcription is stimulated on binding to the CRE of a phosphorylated CREB dimer.hich is held together by leucine zippers. Dimerisation and transcriptional efficacy have been found to be stimulated by phosphorylation at several distinct sites.nd it has thus been suggested that CREB may be regulated by multiple kinases. Sequence analysis of the gene has revealed a cluster of protein kinase A.rotein kinase C.nd casein kinase II consensus recognition sites near the N-terminus of the protein sequence.nd the proximity of these sites to one another indicates the possibility of interaction in a positive or negative fashion to regulate CREB bioactivity.The leucine zipper (see ) is a structure that is believed to mediate the function of several eukaryotic gene regulatory proteins. The zipper consists of a periodic repetition of leucine residues at every seventh position.nd regions containing them appear to span 8 turns of alpha-helix. The leucine side chains that extend from one helix interact with those from a similar helix.ence facilitating dimerisation in the form of a coiled-coil. Leucine zippers are present in many gene regulatory proteins.ncluding the CREB proteins.un/AP1 transcription factors.os oncogene and fos-related proteins.-myc.-myc and N-myc oncogenes.nd so on.
  IPR001630:cAMP response element binding (CREB) protein
The DNA-binding domain of certain eukaryotic transcription factors displays a distinctive helix-turn-helix (HTH) motif. The MafG basic region-leucine zipper (bZIP) protein and the C. elegans Skn-1 transcription factor share this HTH motif. MafG is a member of the Maf family of proteins.hich are a subgroup of bZIP proteins that function as transcriptional regulators of cellular differentiation. Mafs can form either homodimers.r heterodimers with other bZIP proteins through their leucine zipper domains. MafG proteins are small Mafs that lack a putative transactivation domain. The DNA-binding domain of MafG contains the conserved Maf extended homology region (EHR).hich is not present in other bZIP proteins. The EHR together with the basic region are responsible for the DNA-binding specificity of Mafs. Skn-1 is a transcription factor that specifies mesodermal development in C. elegans. Skn-1 and MafG share a conserved DNA-binding motif.owever Skn-1 lacks the leucine zipper dimerisation domain that is found in all bZIP proteins. Skn-1 acts as a monomer. The DNA-binding domains in MafG and Skn-1 share structural similarity.espite a sequence identity of only 25%. The domain fold consists of three (MafG) to four (Skn-1) helices.here the long C-terminal helix protrudes from the domain and binds to DNA. MafG lacks the N-terminal helix of Skn-1. A basic cluster of residues is present on the surface of the domain.hich together with the amino acid sequence motif.XXYAXXCR.orms a DNA-binding surface. MafG and Skn-1 may use a common DNA-binding mode. However.he involvement of helix 2 (H2) in DNA recognition differs between MafG and Skn-1.ith two residues at the beginning of H2 in MafG contributing to the unique DNA-binding specificity of Mafs. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008917:Eukaryotic transcription factor, DNA-binding
IPR011616:bZIP_1 
Evalue:-21.443696975708 
Location:272-332IPR003102:pKID 
Evalue:-17.5686359405518 
Location:99-140IPR001630:LEUZIPPRCREB 
Evalue:0 
Location:154-169IPR001630:LEUZIPPRCREB 
Evalue:0 
Location:233-244
SequencesProtein: CREM_HUMAN (332 aa)
mRNA: NM_181571
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 108 residues, 35455806-35456127Exon2: 43 residues, 35477301-35477425Exon3: 34 residues, 35507822-35507920Exon4: 239 residues, 35508067-35508780Exon5: 2 residues, -Jump to Q96AG7_HUMANExon1: 37 residues, 35456393-35456501Exon2: 34 residues, 35466715-35466813Exon3: 43 residues, 35477301-35477425Exon4: 34 residues, 35507822-35507920Exon5: 49 residues, 35508067-35508210Exon6: 65 residues, 35517133-35517322Exon7: 54 residues, 35535828-35535985Exon8: 436 residues, 35540589-35541891Exon9: 2 residues, -Jump to CREM_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2612 35934343-35937869 ~-4K 4733(+)Loci: 3887 35967182-35970368 ~-3K 4734(FZD8)(-)Loci: 2611 35455806-35541891 ~-86K 4712(+)Link out to UCSC