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0CPT2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCPT2
DescriptionCarnitine o-palmitoyltransferase ii, mitochondrial precursor (ec 2.3.1.21) (cpt ii).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005743 mitochondrial inner membrane (NAS)
0004095 carnitine O-palmitoyltransferase activity (NAS)
0006635 fatty acid beta-oxidation (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
A number of eukaryotic acetyltransferases can.n the basis of sequence similarities.e grouped together into a family. These enzymes include choline o-acetyltransferase ().n enzyme that catalyzes the biosynthesis of the neurotransmitter acetylcholine ; carnitine o-acetyltransferase () ; peroxisomal carnitine octanoyltransferase (). fatty acid beta-oxidation pathway enzyme which is involved in the transport of medium-chain acyl-coenzyme As from peroxisome to mitochondria ; mitochondrial carnitine palmitoyltransferases I and II () (CPT).nzymes involved in fatty acid metabolism and transport ; and Mycoplasma pneumoniae putative acetyltransferase C09_orf600.
  IPR000542:Acyltransferase ChoActase/COT/CPT
IPR000542:Carn_acyltransf 
Evalue:-1e+125 
Location:48-649
SequencesProtein: CPT2_HUMAN (658 aa)
mRNA: BC005172 NM_000098
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords,domains)
transmitter inactivated by its enzyme etc.
sdb:0141 extracellular metabolism  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK00636
  Level 3 annotation:
    carnitine O-palmitoyltransferase
  Level 2 annotation:
    Fatty acid metabolism
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 223 residues, 53434688-53435355Exon2: 29 residues, 53438978-53439059Exon3: 37 residues, 53440582-53440689Exon4: 437 residues, 53448274-53449579Exon5: 312 residues, 53451523-53452455Exon6: 2 residues, -Jump to CPT2_HUMANExon1: 93 residues, 53435079-53435355Exon2: 29 residues, 53438978-53439059Exon3: 35 residues, 53440582-53440683Exon4: 439 residues, 53448268-53449579Exon5: 222 residues, 53451523-53452183Exon6: 2 residues, -Jump to CPT2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2519 53434688-53452455 ~-18K 1515(CPT2)(+)Loci: 3804 53483804-53566314 ~-83K 1520(LRP8)(-)Loci: 2518 53165535-53289870 ~-124K 1506(SCP2)(+)Link out to UCSC