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0CPT1C_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCPT1C
DescriptionCarnitine o-palmitoyltransferase i, mitochondrial brain isoform (ec 2.3.1.21) (carnitine palmitoyltransferase 1c) (cpt ic).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
A number of eukaryotic acetyltransferases can.n the basis of sequence similarities.e grouped together into a family. These enzymes include choline o-acetyltransferase ().n enzyme that catalyzes the biosynthesis of the neurotransmitter acetylcholine ; carnitine o-acetyltransferase () ; peroxisomal carnitine octanoyltransferase (). fatty acid beta-oxidation pathway enzyme which is involved in the transport of medium-chain acyl-coenzyme As from peroxisome to mitochondria ; mitochondrial carnitine palmitoyltransferases I and II () (CPT).nzymes involved in fatty acid metabolism and transport ; and Mycoplasma pneumoniae putative acetyltransferase C09_orf600.
  IPR000542:Acyltransferase ChoActase/COT/CPT
IPR000542:Carn_acyltransf 
Evalue:-227.283996582031 
Location:170-760
SequencesProtein: CPT1C_HUMAN (803 aa)
mRNA: AF357970 NM_152359
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords,domains)
transmitter inactivated by its enzyme etc.
sdb:0141 extracellular metabolism  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK00636
  Level 3 annotation:
    carnitine O-palmitoyltransferase
  Level 2 annotation:
    Fatty acid metabolism
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 64 residues, 54886218-54886409Exon2: 53 residues, 54887307-54887462Exon3: 48 residues, 54892394-54892534Exon4: 59 residues, 54895752-54895924Exon5: 36 residues, 54896385-54896487Exon6: 48 residues, 54896565-54896703Exon7: 28 residues, 54899778-54899856Exon8: 38 residues, 54900075-54900183Exon9: 30 residues, 54900282-54900367Exon10: 67 residues, 54900977-54901173Exon11: 63 residues, 54901299-54901482Exon12: 37 residues, 54902586-54902692Exon13: 41 residues, 54903791-54903908Exon14: 57 residues, 54905388-54905553Exon15: 47 residues, 54905791-54905926Exon16: 53 residues, 54906877-54907030Exon17: 40 residues, 54907804-54907918Exon18: 33 residues, 54908040-54908133Exon19: 106 residues, 54908488-54908800Exon20: 2 residues, -Jump to CPT1C_HUMANExon1: 64 residues, 54886218-54886409Exon2: 53 residues, 54887307-54887462Exon3: 48 residues, 54892394-54892534Exon4: 59 residues, 54895752-54895924Exon5: 36 residues, 54896385-54896487Exon6: 48 residues, 54896565-54896703Exon7: 28 residues, 54899778-54899856Exon8: 38 residues, 54900075-54900183Exon9: 30 residues, 54900282-54900367Exon10: 67 residues, 54900977-54901173Exon11: 63 residues, 54901299-54901482Exon12: 37 residues, 54902586-54902692Exon13: 41 residues, 54903791-54903908Exon14: 57 residues, 54905388-54905553Exon15: 47 residues, 54905791-54905926Exon16: 53 residues, 54906877-54907030Exon17: 40 residues, 54907804-54907918Exon18: 33 residues, 54908040-54908133Exon19: 106 residues, 54908488-54908800Exon20: 2 residues, -Jump to CPT1C_HUMAN  
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Loci Cluster (Details)Loci: 3124 53589943-53639205 ~-49K 19224(GRIN2D)(+)Loci: 3125 53656317-53661179 ~-5K 19226(KCNJ14)(+)Loci: 3126 53747240-53794495 ~-47K 19229(SULT2B1)(+)Loci: 4406 53833083-53841263 ~-8K 19240(CA11)(-)Loci: 4407 53990131-54006113 ~-16K 19255(BCAT2)(-)Loci: 4408 54262487-54268010 ~-6K 19284(-)Loci: 3127 54309429-54313528 ~-4K 19290(LIN7B)(+)Loci: 3128 54314474-54346090 ~-32K 19292(PPFIA3)(+)Loci: 4409 54484705-54520286 ~-36K 19297(SLC6A16)(-)Loci: 3129 54669297-54681299 ~-12K 19311(FLT3LG)(+)Loci: 4410 54854641-54860926 ~-6K 19323(IRF3)(-)Loci: 3130 54886218-54908800 ~-23K 19334(CPT1C)(+)Loci: 3131 54961991-55002179 ~-40K 19337(AP2A1)(+)Loci: 3132 55124271-55129003 ~-5K 19355(ATF5)(+)Loci: 4411 55510576-55524446 ~-14K 19365(KCNC3)(-)Loci: 4412 55817047-55833114 ~-16K 19382(SYT3)(-)Loci: 4413 55856895-55912007 ~-55K 19383(SHANK1)(-)Loci: 3123 53559468-53571439 ~-12K 19220(SYNGR4)(+)Link out to UCSC