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0CPLX2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionComplexin-2 (synaphin-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0006904 vesicle docking during exocytosis (TAS)
Domain Architecture (Details)
InterPro domains assigned to SynO:
This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerise into higher order structures. A peptide from the central.yntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerising. It is thought that oligomerisation of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient.egulated fusion of synaptic vesicles . Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin transmembrane regions that reside in opposing membranes prior to fusion .
SequencesProtein: CPLX2_HUMAN (134 aa)
mRNA: NM_006650
Local Annotation
Synapse Ontology
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
interaction between synaptic vesicle and the scaffold.
sdb:0106 transport of synaptic vesicle in the presynaptic axon  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
sdb:0223 transmitter release  (Evidence:keywords,domains)
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 60 residues, 175156215-175156393Exon2: 28 residues, 175168597-175168677Exon3: 41 residues, 175238260-175238379Exon4: 60 residues, 175238516-175238692Exon5: 1393 residues, 175239456-175243629Exon6: 2 residues, -Jump to CPLX2_HUMAN  
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Loci Cluster (Details)Loci: 3511 175156215-175243629 ~-87K 29972(CPLX2)(+)Loci: 4755 174801325-174802984 ~-2K 29968(DRD1)(-)Link out to UCSC