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0CP27A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCYP27A1
DescriptionCytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008395 steroid hydroxylase activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The cytochrome P450 enzymes constitute a superfamily of haem-thiolate proteins. P450 enzymes usually act as terminal oxidases in multicomponentelectron transfer chains.alled P450-containing monooxygenase systems and are involvedin metabolism of a plethora of both exogenous and endogenous compounds. P450-containingmonooxygenase systems primarily fall into two major classes: bacterial/mitochondrial(type I).nd microsomal (type II). All P450 enzymes can be categorised into twomain groups.he so-called B- and E-classes: P450 proteins of prokaryotic 3-componentsystems and fungal P450nor (CYP55) belong to the B-class; all other known P450 proteinsfrom distinct systems are of the E-class .
  IPR001128:Cytochrome P450
The cytochrome P450 enzymes constitute a superfamily of haem-thiolate proteins. P450 enzymes usually act as terminal oxidases in multicomponentelectron transfer chains.alled P450-containing monooxygenase systems and are involvedin metabolism of a plethora of both exogenous and endogenous compounds. P450-containingmonooxygenase systems primarily fall into two major classes: bacterial/mitochondrial(type I).nd microsomal (type II). All P450 enzymes can be categorised into twomain groups.he so-called B- and E-classes: P450 proteins of prokaryotic 3-componentsystems and fungal P450nor (CYP55) belong to the B-class; all other known P450 proteinsfrom distinct systems are of the E-class .The cytochrome P450 enzymes usually act as terminal oxidases in multicomponentelectron transfer chains.alled P450-containing monooxygenase systems. P450-containingmonooxygenase systems primarily fall into two major classes: bacterial/mitochondrial(type I).nd microsomal (type II). All P450 enzymes can be categorised into twomain groups.he so-called B- and E-classes: P450 proteins of prokaryotic 3-componentsystems and fungal P450nor (CYP55) belong to the B-class; all other known P450 proteinsfrom distinct systems are of the E-class. E-class P450s may be further divided into five subclasses (groups) according to protein sequence similarities. The data suggest that divergence of the P450 superfamily into B- and E-classes.nd further divergence into stable P450 groups within the E-class.ust be very ancient and had occured before the appearance of eukaryotes. Group I is richest in members.onsisting of P450 families CYP1.YP2.YP17.YP21 and CYP71 . The members of the first four families are of vertebrate origin.hile those from CYP71 are derive from plants. CYP1 and CYP2 enzymes mainly metabolise exogenous substrates.hereas CYP17 and CYP21 are involved in metabolism of endogenous physiologically-active compounds.
  IPR002401:E-class P450, group I
IPR001128:p450 
Evalue:-153.88606262207 
Location:61-526
SequencesProtein: CP27A_HUMAN (531 aa)
mRNA: NM_000784
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00488
  Level 3 annotation:
    cytochrome P450, family 27, subfamily A (cholestanetriol 26-monooxygenase)
  Level 2 annotation:
    Bile acid biosynthesis
    Cytochrome P450
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 153 residues, 219354948-219355404Exon2: 65 residues, 219382543-219382734Exon3: 68 residues, 219385188-219385388Exon4: 68 residues, 219385518-219385716Exon5: 59 residues, 219385890-219386063Exon6: 57 residues, 219386987-219387154Exon7: 28 residues, 219387346-219387425Exon8: 73 residues, 219387511-219387724Exon9: 129 residues, 219387877-219388259Exon10: 2 residues, -Jump to CP27A_HUMAN  
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Loci Cluster (Details)Loci: 3213 219232701-219236409 ~-4K 22084(BCS1L)(+)Loci: 3214 219354948-219388259 ~-33K 22089(CYP27A1)(+)Loci: 3215 219532641-219535120 ~-2K 22095(CDK5R2)(+)Loci: 4494 219782737-219791916 ~-9K 22116(ABCB6)(-)Loci: 3216 219991342-219999703 ~-8K 22140(DES)(+)Loci: 3217 220087295-220111732 ~-24K 22148(ACCN4)(+)Loci: 3218 220145197-220148671 ~-3K 22154(INHA)(+)Loci: 4493 219210885-219232599 ~-22K 22082(ZNF142)(-)Link out to UCSC