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0CP24A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCYP24A1
DescriptionCytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005489 electron transporter activity (TAS)
0004497 monooxygenase activity (TAS)
0019825 oxygen binding (TAS)
0006118 electron transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The cytochrome P450 enzymes constitute a superfamily of haem-thiolate proteins. P450 enzymes usually act as terminal oxidases in multicomponentelectron transfer chains.alled P450-containing monooxygenase systems and are involvedin metabolism of a plethora of both exogenous and endogenous compounds. P450-containingmonooxygenase systems primarily fall into two major classes: bacterial/mitochondrial(type I).nd microsomal (type II). All P450 enzymes can be categorised into twomain groups.he so-called B- and E-classes: P450 proteins of prokaryotic 3-componentsystems and fungal P450nor (CYP55) belong to the B-class; all other known P450 proteinsfrom distinct systems are of the E-class .
  IPR001128:Cytochrome P450
The cytochrome P450 enzymes constitute a superfamily of haem-thiolate proteins. P450 enzymes usually act as terminal oxidases in multicomponentelectron transfer chains.alled P450-containing monooxygenase systems and are involvedin metabolism of a plethora of both exogenous and endogenous compounds. P450-containingmonooxygenase systems primarily fall into two major classes: bacterial/mitochondrial(type I).nd microsomal (type II). All P450 enzymes can be categorised into twomain groups.he so-called B- and E-classes: P450 proteins of prokaryotic 3-componentsystems and fungal P450nor (CYP55) belong to the B-class; all other known P450 proteinsfrom distinct systems are of the E-class .The cytochrome P450 enzymes usually act as terminal oxidases in multicomponentelectron transfer chains.alled P450-containing monooxygenase systems. P450-containingmonooxygenase systems primarily fall into two major classes: bacterial/mitochondrial(type I).nd microsomal (type II). All P450 enzymes can be categorised into twomain groups.he so-called B- and E-classes: P450 proteins of prokaryotic 3-componentsystems and fungal P450nor (CYP55) belong to the B-class; all other known P450 proteinsfrom distinct systems are of the E-class. E-class P450s may be further divided into five subclasses (groups) according to protein sequence similarities. The data suggest that divergence of the P450 superfamily into B- and E-classes.nd further divergence into stable P450 groups within the E-class.ust be very ancient and had occured before the appearance of eukaryotes. Group I is richest in members.onsisting of P450 families CYP1.YP2.YP17.YP21 and CYP71 . The members of the first four families are of vertebrate origin.hile those from CYP71 are derive from plants. CYP1 and CYP2 enzymes mainly metabolise exogenous substrates.hereas CYP17 and CYP21 are involved in metabolism of endogenous physiologically-active compounds.
  IPR002401:E-class P450, group I
P450 enzymes constitute a superfamily of haem-thiolate proteins .idely distributed in bacteria.ungi.lants and animals. The enzymesare involved in metabolism of a plethora of both exogenous and endogenouscompounds . Usually.hey act as terminal oxidases in multi-componentelectron transfer chains.alled P450-containing monooxygenase systems. On the basis of sequence similarity.ll P450s can be categorised into 2 main groups.he so-called B- and E-classes: P450 proteins of prokaryotic 3-component systems and fungal P450nor (CYP55) belong to the B-class; all other known P450s from distinct systems are of the E-class. By contrast with the B-class.ontaining water-soluble haemoproteins.ost E-class P450s are membrane-bound. Membranous P450s can be divided intothose from the inner mitochondrial membrane (mitochondrial type).nd thosefrom membranes of the endoplasmic reticulum (ER) (microsomal type). In themitochondrial P450-containing monooxygenase system.450 can be reduced bythe 2Fe-2S iron-sulphur protein adrenodoxin.hich can accept electronsfrom NADPH-dependent adrenodoxin reductase. Both adrenodoxin andadrenodoxin reductase are soluble.nd located in the mitochondrial matrix . Microsomal P450s depend on a single NADPH:P450 reductase; the P450sand the reductase are located on the cytosolic side of the ER membrane.ndare anchored to the membrane by hydrophobic amino-terminal segments . To date.nly animal mitochondrial P450s have been sequenced. A cDNA encoding 25-hydroxyvitamin D3 24-hydroxylase (P450cc24) has beenisolated from rat kidney. The cDNA contained a 1542bp open readingframe encoding 514 amino acids.ncluding an N-terminal presequence typicalof mitochondrial enzymes. The sequence shows less than 30% similarity to those of other cytochrome P450s.nd hence P450cc24 constitutes a novelP450 family . The enzyme catalyses the conversion of 25-hydroxyvitaminD3 and 1-alpha.5-dihydroxyvitamin D3 to 24.5-dihydroxyvitamin D3 and1.4.5-trihydroxyvitamin D3.espectively .
  IPR002949:Mitochondrial P450, CC24
IPR001128:p450 
Evalue:-107.886054992676 
Location:58-513
SequencesProtein: CP24A_HUMAN (514 aa)
mRNA: NM_000782
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK07436
  Level 3 annotation:
    cytochrome P450, family 24, subfamily A (25-hydroxyvitamin D3 24-hydroxylase)
  Level 2 annotation:
    Cytochrome P450
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 438 residues, 52203394-52204707Exon2: 42 residues, 52207114-52207235Exon3: 68 residues, 52207333-52207531Exon4: 28 residues, 52208031-52208110Exon5: 57 residues, 52208902-52209069Exon6: 50 residues, 52212662-52212808Exon7: 39 residues, 52214397-52214509Exon8: 32 residues, 52215687-52215779Exon9: 34 residues, 52219537-52219634Exon10: 33 residues, 52221522-52221616Exon11: 65 residues, 52222854-52223045Exon12: 223 residues, 52223267-52223931Exon13: 2 residues, -Jump to CP24A_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3267 52525672-52701116 ~-175K 23369(DOK5)(+)Loci: 4533 52203394-52223931 ~-21K 23362(CYP24A1)(-)Link out to UCSC