SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0COX42_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCOX4I2
DescriptionCytochrome c oxidase subunit iv isoform 2, mitochondrial precursor (ec 1.9.3.1) (cox iv-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005751 respiratory chain complex IV (sensu Eukaryota) (IC)
0004129 cytochrome-c oxidase activity (IDA)
0045333 cellular respiration (NAS)
0006118 electron transport (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/748841434.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cytochrome c oxidase. 13 sub-unit complex.s the terminal oxidase in the mitochondrial electron transport chain. Thisfamily is composed of cytochrome c oxidase subunit IV. The Dictyostelium discoideum member of this family is called COX VI. The Saccharomyces cerevisiae protein YGX6_YEAST appears to be the yeast COX IV subunit.
  IPR004203:Cytochrome c oxidase subunit IV
Cytochrome c oxidase (COX) subunit IV is a mitochondrial inner membrane protein that forms part of the 13-subunit COX complex.he terminal oxidase in the mitochondrial electron transport chain. The enzyme catalyses the reaction: 4 ferrocytochrome c + O(2) = 4 ferricytochrome c + 2 H(2)O This polypeptide belongs to a wider family of proteins that includes the Dictyostelium discoideum COX VI and the Saccharomyces cerevisiae protein YGX6. The 3D structure of the whole bovine heart cytochrome c oxidase has been determined to 2.8A resolution by means of X-ray crystallography . The structure reveals 13 different subunits.ive phosphatidyl ethanolamines.hree phosphatidyl glycerols.wo cholates.wo haems A.nd a number of copper.agnesium and zinc ions . A hydrogen-bonded system.ncluding a propionate of heme A.art of the peptide backbone.nd an imidazole ligand of CuA.ay provide an electron transfer pathway between CuA and heme A .
  IPR013288:Cytochrome c oxidase subunit 4
IPR004203:COX4 
Evalue:-42 
Location:29-171
SequencesProtein: COX42_HUMAN (171 aa)
mRNA: NM_032609
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 26 residues, 29689351-29689426Exon2: 29 residues, 29690481-29690563Exon3: 57 residues, 29691396-29691561Exon4: 46 residues, 29694867-29694999Exon5: 78 residues, 29696231-29696461Exon6: 2 residues, -Jump to COX42_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3245 29689351-29696461 ~-7K 22847(COX4I2)(+)Loci: 4514 29715923-29774317 ~-58K 22848(BCL2L1)(-)Loci: 3243 29492071-29501720 ~-10K 22838(DEFB123)(+)Link out to UCSC