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0COX11_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCOX11
DescriptionCytochrome c oxidase assembly protein cox11, mitochondrial precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004129 cytochrome-c oxidase activity (TAS)
0005489 electron transporter activity (TAS)
0008535 cytochrome c oxidase complex assembly (TAS)
0007585 respiratory gaseous exchange (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein. In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in subunit I.or example haems a and a3.nd the magnesium/manganese centre. Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units . The C-terminal region of the protein is known to form a dimer. Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111.08 and 210) in Saccharomyces cerevisiae (). Met 224 is also thought to play a role in copper transfer or stabilising the copper site .
  IPR007533:Cytochrome c oxidase assembly protein CtaG/Cox11
IPR007533:CtaG_Cox11 
Evalue:-114.920822143555 
Location:113-264
SequencesProtein: COX11_HUMAN (276 aa)
mRNA: NM_004375
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK02258
  Level 3 annotation:
    cytochrome c oxidase subunit XI assembly protein
  Level 2 annotation:
    Oxidative phosphorylation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 70 residues, 50384265-50384472Exon2: 601 residues, 50393478-50395275Exon3: 44 residues, 50395665-50395791Exon4: 54 residues, 50397056-50397212Exon5: 139 residues, 50400640-50401053Exon6: 2 residues, -Jump to COX11_HUMAN  
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Loci Cluster (Details)Loci: 4302 50824972-50854340 ~-29K 16258(MMD)(-)Loci: 4301 50384265-50401053 ~-17K 16254(COX11)(-)Link out to UCSC