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0COX10_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCOX10
DescriptionProtoheme ix farnesyltransferase, mitochondrial precursor (ec 2.5.1.-) (heme o synthase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004311 farnesyltranstransferase activity (TAS)
0006783 heme biosynthesis (TAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
The COX10/ctaB/cyoE signature is found in prenyltransferases including bacterial 4-hydroxybenzoate octaprenyltransferase (gene ubiA); yeast mitochondrial para-hydroxybenzoate--polyprenyltransferase (gene COQ2); and protoheme IX farnesyltransferase (heme O synthase) from yeast and mammals(gene COX10).nd from bacteria (genes cyoE or ctaB) . These are integral membrane proteins.hich probably contain seven transmembrane segments. The signature is also found in cytochrome C oxidase assembly factor. The complexity of cytochrome C oxidase requires assistance in building the complex.nd this is carried out by the cytochrome C oxidase assembly factor.
  IPR000537:UbiA prenyltransferase
This family describes protoheme IX farnesyltransferase.lso called haeme O synthase.n enzyme that creates an intermediate in the biosynthesis of haeme A . Prior to the description of its enzymatic function.his protein was often called a cytochrome o ubiquinol oxidase assembly factor.
  IPR006369:Protoheme IX farnesyltransferase
IPR000537:UbiA 
Evalue:-83.6382751464844 
Location:166-430
SequencesProtein: COX10_HUMAN (443 aa)
mRNA: NM_001303
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK02257
  Level 3 annotation:
    protoheme IX farnesyltransferase
  Level 2 annotation:
    Oxidative phosphorylation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 83 residues, 13913443-13913690Exon2: 46 residues, 13918364-13918498Exon3: 109 residues, 13920776-13921098Exon4: 43 residues, 13946159-13946284Exon5: 25 residues, 14003918-14003989Exon6: 79 residues, 14036030-14036263Exon7: 624 residues, 14050851-14052717Exon8: 2 residues, -Jump to COX10_HUMAN  
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