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0COR1A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCORO1A
DescriptionCoronin-1a (coronin-like protein p57) (coronin-like protein a) (clipina) (tryptophan aspartate-containing coat protein) (taco).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015629 actin cytoskeleton (TAS)
0005765 lysosomal membrane (TAS)
0005198 structural molecule activity (TAS)
0007067 mitosis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
IPR001680:WD40 
Evalue:-9.74472713470459 
Location:70-109IPR001680:WD40 
Evalue:-8.04575729370117 
Location:119-159IPR001680:WD40 
Evalue:-5.55284214019775 
Location:162-203
SequencesProtein: COR1A_HUMAN (461 aa)
mRNA: NM_007074
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 30102426-30102547Exon2: 68 residues, 30104030-30104229Exon3: 43 residues, 30105419-30105542Exon4: 45 residues, 30105637-30105767Exon5: 63 residues, 30105860-30106045Exon6: 42 residues, 30106203-30106323Exon7: 37 residues, 30106546-30106651Exon8: 50 residues, 30106763-30106909Exon9: 21 residues, 30107013-30107071Exon10: 74 residues, 30107182-30107398Exon11: 74 residues, 30107681-30107897Exon12: 2 residues, -Jump to COR1A_HUMAN  
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Loci Cluster (Details)Loci: 2933 29709562-29724205 ~-15K 13857(KIF22)(+)Loci: 4218 29924337-29929902 ~-6K 13883(DOC2A)(-)Loci: 2934 29971991-29989235 ~-17K 13889(ALDOA)(+)Loci: 2935 30102426-30107897 ~-5K 13900(CORO1A)(+)Loci: 2936 30113969-30123150 ~-9K 13906(SULT1A3)(+)Loci: 2932 29374627-29383801 ~-9K 13851(SULT1A3)(+)Link out to UCSC