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0COPB2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCOPB2
DescriptionCoatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030126 COPI vesicle coat (IDA)
0006891 intra-Golgi transport (IDA)
0006890 retrograde transport, Golgi to ER (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
RET1P.he alpha-subunit of the coatomer complex in Saccharomyces cerevisiae.articipates in membrane transport between the endoplasmic reticulum and Golgi apparatus. The protein contains six WD-40 repeat motifs in its N-terminal region .
  IPR006692:Coatomer WD associated region
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
IPR006692:Coatomer_WDAD 
Evalue:-287.53759765625 
Location:318-777IPR001680:WD40 
Evalue:-12 
Location:218-256IPR001680:WD40 
Evalue:-10.3767509460449 
Location:131-170IPR001680:WD40 
Evalue:-9.74472713470459 
Location:88-126IPR001680:WD40 
Evalue:-8.36653137207031 
Location:174-214IPR001680:WD40 
Evalue:-3.0915150642395 
Location:4-42IPR001680:WD40 
Evalue:-2.92081880569458 
Location:46-84IPR001680:WD_REPEATS_1 
Evalue:0 
Location:0-0
SequencesProtein: COPB2_HUMAN (905 aa)
mRNA: NM_004766
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 123 residues, 140559124-140559490Exon2: 26 residues, 140559731-140559803Exon3: 25 residues, 140560275-140560344Exon4: 62 residues, 140560529-140560710Exon5: 33 residues, 140560801-140560894Exon6: 73 residues, 140562612-140562827Exon7: 39 residues, 140563938-140564049Exon8: 71 residues, 140568099-140568307Exon9: 45 residues, 140568546-140568677Exon10: 50 residues, 140569676-140569820Exon11: 37 residues, 140570792-140570899Exon12: 31 residues, 140570987-140571076Exon13: 39 residues, 140573254-140573365Exon14: 68 residues, 140574744-140574944Exon15: 49 residues, 140575197-140575340Exon16: 35 residues, 140576020-140576120Exon17: 51 residues, 140576999-140577146Exon18: 51 residues, 140579572-140579721Exon19: 44 residues, 140580578-140580705Exon20: 31 residues, 140580911-140580998Exon21: 48 residues, 140584829-140584967Exon22: 26 residues, 140591079-140591151Exon23: 2 residues, -Jump to COPB2_HUMAN  
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Loci Cluster (Details)Loci: 4640 140559124-140591151 ~-32K 26599(COPB2)(-)Loci: 3378 140545550-140558755 ~-13K 26595(MRPS22)(+)Link out to UCSC