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0COMT_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCOMT
DescriptionCatechol o-methyltransferase (ec 2.1.1.6).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005792 microsome (TAS)
0005625 soluble fraction (TAS)
0008171 O-methyltransferase activity (TAS)
0005515 protein binding (IPI)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Members of this family are O-methyltransferases. The family includes also bacterial O-methyltransferases that may be involved in antibiotic production .
  IPR002935:O-methyltransferase, family 3
IPR002935:Methyltransf_3 
Evalue:-4.67778062820435 
Location:67-236
SequencesProtein: COMT_HUMAN (271 aa)
mRNA: NM_000754
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK00545
  Level 3 annotation:
    catechol O-methyltransferase
  Level 2 annotation:
    Tyrosine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 38 residues, 18309308-18309420Exon2: 32 residues, 18328721-18328812Exon3: 98 residues, 18330049-18330338Exon4: 66 residues, 18331088-18331282Exon5: 46 residues, 18331690-18331822Exon6: 158 residues, 18336058-18336528Exon7: 2 residues, -Jump to COMT_HUMAN  
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Loci Cluster (Details)Loci: 4555 16596905-16637258 ~-40K 24143(BID)(-)Loci: 3295 16973558-16994498 ~-21K 24153(TUBA8)(+)Loci: 4556 17280294-17304066 ~-24K 24158(PRODH)(-)Loci: 4557 17543094-17546285 ~-3K 24164(SLC25A1)(-)Loci: 4558 17698223-17799219 ~-101K 24167(HIRA)(-)Loci: 3296 18081986-18090842 ~-9K 24176(SEPT5)(+)Loci: 4559 18243045-18309515 ~-66K 24188(TXNRD2)(-)Loci: 3297 18309308-18336528 ~-27K 24191(COMT)(+)Loci: 3294 16423182-16453647 ~-30K 24138(SLC25A18)(+)Link out to UCSC