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0CO3A1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCOL3A1
DescriptionCollagen alpha 1(iii) chain precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005586 collagen type III (TAS)
0008015 circulation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The vWF domain is found in various plasma proteins:complement factors B.2.R3 and CR4; the integrins (I-domains); collagen types VI.II.II and XIV; and other extracellular proteins . Although the majority of VWA-containing proteins are extracellular.he most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription.NA repair.ibosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteinsthat incorporate vWF domains participate in numerous biological events(e.g. cell adhesion.igration.oming.attern formation.nd signaltransduction).nvolving interaction with a large array of ligands . A number of human diseases arise from mutations in VWA domains. Secondary structure prediction from 75 aligned vWF sequences has revealed a largely alternating sequence of alpha-helices and beta-strands .The domain is named after the von Willebrand factor (VWF) type C repeat which is found in multidomain protein/multifunctional proteins involved in maintaining homeostasis . For the von Willebrand factor the duplicated VWFC domain is thought to participate in oligomerization.ut not in the initial dimerization step . The presence of this region in a number of other complex-forming proteins points to the possible involvment of the VWFC domain in complex formation.
  IPR001007:von Willebrand factor, type C
Members of this family belong to the collagen superfamily .Collagens are generally extracellular structural proteinsinvolved in formation of connective tissue structure.The sequence is predominantly repeats of the G-X-Y and the polypeptide chainsform a triple helix. The first position of the repeat isglycine.he second and third positions can be any residuebut are frequently proline and hydroxyproline. Collagensare post-translationally modified by proline hydroxylaseto form the hydroxyproline residues. Defectivehydroxylation is the cause of scurvy.Some members of the collagen superfamily are not involvedin connective tissue structure but share the same triplehelical structure.
  IPR008160:Collagen triple helix repeat
Collagens contain a large number of globular domains in between theregions of triple helical repeats .These domains are involved in binding diverse substrates.One of these domains is found at the C terminus of fibrillar collagens.The exact function of this domain is unknown.
  IPR000885:Fibrillar collagen, C-terminal
Members of this family belong to the collagen superfamily . Collagens are generally extracellular structural proteinsinvolved in formation of connective tissue structure. The sequence is predominantly repeats of the G-X-Y and the polypeptide chainsform a triple helix. The first position of the repeat isglycine.he second and third positions can be any residuebut are frequently proline and hydroxyproline. Collagensare post-translationally modified by proline hydroxylaseto form the hydroxyproline residues. Defectivehydroxylation is the cause of scurvy.Some members of the collagen superfamily are not involvedin connective tissue structure but share the same triplehelical structure.
  IPR008161:Collagen helix repeat
This SSF signature was designed to identify serine proteases inhibitors belonging to the grasshopper PMP inhibitor family .nd to the desert locust SGCI/SGTI family .oth of which belong to MEROPS inhibitor family I19.lan IW. The PMP inhibitors have a conserved array of six cysteine residues (Cys-Xaa(9-12)-Cys-Asn-Xaa-Cys-Xaa-Cys-Xaa(2-3)-Gly-Xaa(3-4)-Cys-Thr-Xaa(3)-Cys).hich are involved in an identical disulfide bridge pattern (Cys(1)-Cys(4).ys(2)-Cys(6).ys(3)-Cys(5)) . Some of the PMP inhibitors are fucosylated.he function of the fucose moiety being unknown.The signature also matches many proteins which are not known to be proteinase inhibitors.nd which are annotated as mucin.CO-spondin.ollagen alpha 1.agged1.agged2 or von Willebrand factor.ype D and type C.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009041:Proteinase inhibitor, PMP and SGCI
IPR000885:COLFI 
Evalue:-167.657577319178 
Location:1231-1466IPR001007:VWC 
Evalue:-23.4317989349365 
Location:32-88IPR008160:Collagen 
Evalue:-19.9586067199707 
Location:1077-1136IPR008160:Collagen 
Evalue:-19.6989707946777 
Location:234-293IPR008160:Collagen 
Evalue:-17.075719833374 
Location:1137-1196IPR008160:Collagen 
Evalue:-16.9586067199707 
Location:534-593IPR008160:Collagen 
Evalue:-16.6575775146484 
Location:294-353IPR008160:Collagen 
Evalue:-16.443696975708 
Location:414-473IPR008160:Collagen 
Evalue:-16.32790184021 
Location:354-413IPR008160:Collagen 
Evalue:-16.1079063415527 
Location:168-227IPR008160:Collagen 
Evalue:-15.7212467193604 
Location:957-1016IPR008160:Collagen 
Evalue:-15.6382722854614 
Location:897-956IPR008160:Collagen 
Evalue:-15.3098039627075 
Location:474-533IPR008160:Collagen 
Evalue:-14.4436979293823 
Location:1017-1076IPR008160:Collagen 
Evalue:-13.795880317688 
Location:714-773IPR008160:Collagen 
Evalue:-13.6382722854614 
Location:777-836IPR008160:Collagen 
Evalue:-12.0315170288086 
Location:837-896IPR008160:Collagen 
Evalue:-11.1023731231689 
Location:594-653IPR008160:Collagen 
Evalue:-10.3872165679932 
Location:654-713IPR008160:Collagen 
Evalue:-4.04095840454102 
Location:102-139
SequencesProtein: CO3A1_HUMAN (1466 aa)
mRNA: NM_000090
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentK06236
  Level 3 annotation:
    collagen, type I/II/III/V/XI, alpha
  Level 2 annotation:
    ECM-receptor interaction
    CAM ligands
    Focal adhesion
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 66 residues, 189547343-189547539Exon2: 69 residues, 189557730-189557933Exon3: 19 residues, 189558167-189558218Exon4: 40 residues, 189558635-189558749Exon5: 29 residues, 189560029-189560110Exon6: 20 residues, 189561051-189561105Exon7: 20 residues, 189561560-189561614Exon8: 20 residues, 189562366-189562420Exon9: 20 residues, 189563066-189563120Exon10: 20 residues, 189563277-189563331Exon11: 20 residues, 189563974-189564028Exon12: 17 residues, 189564457-189564502Exon13: 20 residues, 189564639-189564693Exon14: 17 residues, 189565154-189565199Exon15: 20 residues, 189565857-189565911Exon16: 35 residues, 189566331-189566430Exon17: 17 residues, 189567008-189567053Exon18: 35 residues, 189567204-189567303Exon19: 20 residues, 189567511-189567565Exon20: 38 residues, 189567694-189567802Exon21: 20 residues, 189568016-189568070Exon22: 35 residues, 189568662-189568761Exon23: 20 residues, 189569095-189569149Exon24: 35 residues, 189569368-189569467Exon25: 20 residues, 189570135-189570189Exon26: 20 residues, 189570306-189570360Exon27: 20 residues, 189570670-189570724Exon28: 20 residues, 189571236-189571290Exon29: 17 residues, 189571644-189571689Exon30: 35 residues, 189572255-189572354Exon31: 38 residues, 189572440-189572548Exon32: 20 residues, 189572812-189572866Exon33: 20 residues, 189574367-189574421Exon34: 20 residues, 189574506-189574560Exon35: 20 residues, 189575268-189575322Exon36: 38 residues, 189575925-189576033Exon37: 20 residues, 189576381-189576435Exon38: 20 residues, 189576704-189576758Exon39: 56 residues, 189576952-189577114Exon40: 38 residues, 189577227-189577335Exon41: 38 residues, 189578320-189578428Exon42: 20 residues, 189579176-189579230Exon43: 38 residues, 189579315-189579423Exon44: 20 residues, 189579907-189579961Exon45: 38 residues, 189580470-189580578Exon46: 20 residues, 189580855-189580909Exon47: 38 residues, 189581005-189581113Exon48: 101 residues, 189581894-189582192Exon49: 64 residues, 189583148-189583336Exon50: 83 residues, 189583618-189583861Exon51: 375 residues, 189584598-189585717Exon52: 2 residues, -Jump to CO3A1_HUMAN  
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