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0CO2A1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCOL2A1
DescriptionCollagen alpha 1(ii) chain precursor .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0001501 skeletal development (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Members of this family belong to the collagen superfamily .Collagens are generally extracellular structural proteinsinvolved in formation of connective tissue structure.The sequence is predominantly repeats of the G-X-Y and the polypeptide chainsform a triple helix. The first position of the repeat isglycine.he second and third positions can be any residuebut are frequently proline and hydroxyproline. Collagensare post-translationally modified by proline hydroxylaseto form the hydroxyproline residues. Defectivehydroxylation is the cause of scurvy.Some members of the collagen superfamily are not involvedin connective tissue structure but share the same triplehelical structure.
  IPR008160:Collagen triple helix repeat
Collagens contain a large number of globular domains in between theregions of triple helical repeats .These domains are involved in binding diverse substrates.One of these domains is found at the C terminus of fibrillar collagens.The exact function of this domain is unknown.
  IPR000885:Fibrillar collagen, C-terminal
Members of this family belong to the collagen superfamily . Collagens are generally extracellular structural proteinsinvolved in formation of connective tissue structure. The sequence is predominantly repeats of the G-X-Y and the polypeptide chainsform a triple helix. The first position of the repeat isglycine.he second and third positions can be any residuebut are frequently proline and hydroxyproline. Collagensare post-translationally modified by proline hydroxylaseto form the hydroxyproline residues. Defectivehydroxylation is the cause of scurvy.Some members of the collagen superfamily are not involvedin connective tissue structure but share the same triplehelical structure.
  IPR008161:Collagen helix repeat
IPR000885:COLFI 
Evalue:-182.180456064458 
Location:1183-1418IPR008160:Collagen 
Evalue:-16.9208183288574 
Location:189-248IPR008160:Collagen 
Evalue:-15.8239088058472 
Location:669-728IPR008160:Collagen 
Evalue:-15.2076082229614 
Location:732-791IPR008160:Collagen 
Evalue:-14.9208183288574 
Location:549-608IPR008160:Collagen 
Evalue:-14.5686359405518 
Location:489-548IPR008160:Collagen 
Evalue:-14.508638381958 
Location:1032-1091IPR008160:Collagen 
Evalue:-13.6989698410034 
Location:249-308IPR008160:Collagen 
Evalue:-13.5376024246216 
Location:915-974IPR008160:Collagen 
Evalue:-13.4317979812622 
Location:792-851IPR008160:Collagen 
Evalue:-13.2839965820313 
Location:609-668IPR008160:Collagen 
Evalue:-12.6020603179932 
Location:309-368IPR008160:Collagen 
Evalue:-11.4685211181641 
Location:429-488IPR008160:Collagen 
Evalue:-11.2596368789673 
Location:975-1031IPR008160:Collagen 
Evalue:-11.236572265625 
Location:130-188IPR008160:Collagen 
Evalue:-11.2006597518921 
Location:369-428IPR008160:Collagen 
Evalue:-10.9208183288574 
Location:852-911IPR008160:Collagen 
Evalue:-9.82390880584717 
Location:48-107IPR008160:Collagen 
Evalue:-6.13076829910278 
Location:1092-1151
SequencesProtein: CO2A1_HUMAN (1418 aa)
mRNA: NM_001844 NM_033150
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentK06236
  Level 3 annotation:
    collagen, type I/II/III/V/XI, alpha
  Level 2 annotation:
    ECM-receptor interaction
    CAM ligands
    Focal adhesion
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 196 residues, 46653017-46653603Exon2: 83 residues, 46654138-46654381Exon3: 64 residues, 46654724-46654912Exon4: 98 residues, 46655366-46655655Exon5: 38 residues, 46656012-46656120Exon6: 20 residues, 46656563-46656617Exon7: 38 residues, 46656861-46656969Exon8: 20 residues, 46657151-46657205Exon9: 38 residues, 46657369-46657477Exon10: 20 residues, 46657649-46657703Exon11: 38 residues, 46658059-46658167Exon12: 38 residues, 46658340-46658448Exon13: 56 residues, 46658646-46658808Exon14: 20 residues, 46659560-46659614Exon15: 20 residues, 46660058-46660112Exon16: 38 residues, 46660603-46660711Exon17: 20 residues, 46660964-46661018Exon18: 20 residues, 46661392-46661446Exon19: 20 residues, 46661825-46661879Exon20: 20 residues, 46662156-46662210Exon21: 38 residues, 46662551-46662659Exon22: 35 residues, 46662897-46662996Exon23: 17 residues, 46663142-46663187Exon24: 20 residues, 46663434-46663488Exon25: 20 residues, 46663732-46663786Exon26: 20 residues, 46664136-46664190Exon27: 20 residues, 46664595-46664649Exon28: 35 residues, 46665044-46665143Exon29: 20 residues, 46665583-46665637Exon30: 35 residues, 46665777-46665876Exon31: 20 residues, 46665961-46666015Exon32: 38 residues, 46666385-46666493Exon33: 20 residues, 46666884-46666938Exon34: 35 residues, 46667127-46667226Exon35: 17 residues, 46667318-46667363Exon36: 35 residues, 46667660-46667759Exon37: 20 residues, 46669277-46669331Exon38: 17 residues, 46669810-46669855Exon39: 20 residues, 46672927-46672981Exon40: 17 residues, 46673507-46673552Exon41: 20 residues, 46673858-46673912Exon42: 20 residues, 46674043-46674097Exon43: 20 residues, 46674473-46674527Exon44: 20 residues, 46675304-46675358Exon45: 20 residues, 46675759-46675813Exon46: 17 residues, 46675924-46675969Exon47: 28 residues, 46676597-46676675Exon48: 36 residues, 46677655-46677757Exon49: 20 residues, 46677920-46677974Exon50: 13 residues, 46678081-46678114Exon51: 13 residues, 46678218-46678251Exon52: 7 residues, 46678464-46678481Exon53: 71 residues, 46679968-46680175Exon54: 82 residues, 46684286-46684528Exon55: 2 residues, -Jump to CO2A1_HUMANExon1: 196 residues, 46653017-46653603Exon2: 83 residues, 46654138-46654381Exon3: 64 residues, 46654724-46654912Exon4: 98 residues, 46655366-46655655Exon5: 38 residues, 46656012-46656120Exon6: 20 residues, 46656563-46656617Exon7: 38 residues, 46656861-46656969Exon8: 20 residues, 46657151-46657205Exon9: 38 residues, 46657369-46657477Exon10: 20 residues, 46657649-46657703Exon11: 38 residues, 46658059-46658167Exon12: 38 residues, 46658340-46658448Exon13: 56 residues, 46658646-46658808Exon14: 20 residues, 46659560-46659614Exon15: 20 residues, 46660058-46660112Exon16: 38 residues, 46660603-46660711Exon17: 20 residues, 46660964-46661018Exon18: 20 residues, 46661392-46661446Exon19: 20 residues, 46661825-46661879Exon20: 20 residues, 46662156-46662210Exon21: 38 residues, 46662551-46662659Exon22: 35 residues, 46662897-46662996Exon23: 17 residues, 46663142-46663187Exon24: 20 residues, 46663434-46663488Exon25: 20 residues, 46663732-46663786Exon26: 20 residues, 46664136-46664190Exon27: 20 residues, 46664595-46664649Exon28: 35 residues, 46665044-46665143Exon29: 20 residues, 46665583-46665637Exon30: 35 residues, 46665777-46665876Exon31: 20 residues, 46665961-46666015Exon32: 38 residues, 46666385-46666493Exon33: 20 residues, 46666884-46666938Exon34: 35 residues, 46667127-46667226Exon35: 17 residues, 46667318-46667363Exon36: 35 residues, 46667660-46667759Exon37: 20 residues, 46669277-46669331Exon38: 17 residues, 46669810-46669855Exon39: 20 residues, 46672927-46672981Exon40: 17 residues, 46673507-46673552Exon41: 20 residues, 46673858-46673912Exon42: 20 residues, 46674043-46674097Exon43: 20 residues, 46674473-46674527Exon44: 20 residues, 46675304-46675358Exon45: 20 residues, 46675759-46675813Exon46: 17 residues, 46675924-46675969Exon47: 28 residues, 46676597-46676675Exon48: 36 residues, 46677655-46677757Exon49: 20 residues, 46677920-46677974Exon50: 13 residues, 46678081-46678114Exon51: 13 residues, 46678218-46678251Exon52: 7 residues, 46678464-46678481Exon53: 82 residues, 46684286-46684528Exon54: 2 residues, -Jump to CO2A1_HUMAN  
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Loci Cluster (Details)Loci: 2747 46453287-46462800 ~-10K 8718(+)Loci: 4026 46653017-46684528 ~-32K 8730(COL2A1)(-)Loci: 4025 46417293-46438888 ~-22K 8714(RAPGEF3)(-)Link out to UCSC