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0CNR2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCNR2
DescriptionCannabinoid receptor 2 (cb2) (cb-2) (cx5).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004949 cannabinoid receptor activity (TAS)
0007610 behavior (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0006955 immune response (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The ability of marijuana to activate the cannabinoid receptor provides amolecular explanation for its psychoactive effects and other CNS actions(which include hallucinations.emory deficits.ltered time and spaceperception.NS depression and appetite stimulation). The endogenousligand at the cannabinoid receptor is unknown.lthough it may be aderivative of arachidonic acid. The cannabinoid receptor is widespreadthroughout the CNS.igh levels occurring in the dendate gyrus.ippocampusand cerebral cortex.ith more moderate levels in the hypothalamus andamygdala. It is also present in various cell lines.nd in the peripheryit is found in the testis and vas deferens .
  IPR002230:Cannabinoid receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The ability of marijuana to activate the cannabinoid receptor provides amolecular explanation for its psychoactive effects and other CNS actions(which include hallucinations.emory deficits.ltered time and spaceperception.NS depression and appetite stimulation) . The endogenousligand at the cannabinoid receptor is unknown.lthough it may be aderivative of arachidonic acid. The cannabinoid receptor is widespreadthroughout the CNS.igh levels occurring in the dendate gyrus.ippocampusand cerebral cortex.ith more moderate levels in the hypothalamus andamygdala. It is also present in various cell lines.nd in the peripheryit is found in the testis and vas deferens .
  IPR001551:Cannabinoid receptor, type 2
IPR000276:7tm_1 
Evalue:-58.2218475341797 
Location:50-299IPR001551:CANABINOID2R 
Evalue:0 
Location:7-25IPR001551:CANABINOID2R 
Evalue:0 
Location:325-343IPR001551:CANABINOID2R 
Evalue:0 
Location:307-324
SequencesProtein: CNR2_HUMAN (360 aa)
mRNA: NM_001841
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04278
  Level 3 annotation:
    cannabinoid receptor 2 (macrophage)
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 565 residues, 24073047-24074739Exon2: 29 residues, 24112322-24112404Exon3: 2 residues, -Jump to CNR2_HUMAN  
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Loci Cluster (Details)Loci: 3779 23390975-23393809 ~-3K 651(HTR1D)(-)Loci: 3780 23757042-23758872 ~-2K 667(ID3)(-)Loci: 3781 24000954-24024536 ~-24K 680(HMGCL)(-)Loci: 3782 24073047-24112404 ~-39K 686(CNR2)(-)Loci: 3783 24168159-24179408 ~-11K 691(FUSIP1)(-)Loci: 2490 23218532-23282771 ~-64K 646(AOF2)(+)Link out to UCSC