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0CNGA1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCNGA1
Descriptioncgmp-gated cation channel alpha 1 (cng channel alpha 1) (cng-1) (cng1) (cyclic nucleotide gated channel alpha 1) (cyclic nucleotide gated channel, photoreceptor) (cyclic-nucleotide-gated cation channel 1) (rod photoreceptor cgmp-gated channel alpha subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0006810 transport (TAS)
0007601 visual perception (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.The first EAG K+ channel was identified in Drosophila melanogaster.ollowing a screen for mutations giving rise to behavioural abnormalities. Disruption of the Eag gene caused an ether-induced.eg-shaking behaviour. Subsequent studies have revealed a conserved multi-gene family of EAG-like K+ channels.hich are present in human and many other species. Based on the varying functional properties of the channels.he family has been divided into 3 subfamilies: EAG.LK and ERG. Interestingly.aenorhabditis elegans appears to lack the ELK type .
  IPR003938:EAG/ELK/ERG potassium channel
InterPro domains unassigned to SynO:
This group of proteins is found in sodium.otassium.nd calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channels proteins the domain is repeated four times.hereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
  IPR005821:Ion transport
Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues . The best studied of these proteins is the prokaryotic catabolite gene activator (alsoknown as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three alpha-helices anda distinctive eight-stranded.ntiparallel beta-barrel structure. There are six invariant amino acids in this domain.hree of which are glycine residues that are thought to be essential for maintenance of the structural integrity ofthe beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclicnucleotide-binding domain. The cAPKs are composed of two different subunits. catalytic chain and a regulatory chain.hich contains both copies of the domain. The cGPKs are single chain enzymes that include the two copies of the domainin their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two suchcations channels have been fully characterized.ne is found in rod cells where it plays a role in visual signaltransduction.
  IPR000595:Cyclic nucleotide-binding
In prokaryotes.he nucleotide exchange factor GrpE and the chaperone DnaJ are required for nucleotide binding of the molecular chaperone DnaK . The DnaK reaction cycle involves rapid peptide binding and release.hich is dependent upon nucleotide binding. DnaJ accelerates the hydrolysis of ATP by DnaK.hich enables the ADP-bound DnaK to tightly bind peptide. GrpE catalyses the release of ADP from DnaK.hich is required for peptide release. In eukaryotes.rpE is essential for mitochondrial Hsp70 function.owever the cytosolic Hsp70 homologues are GrpE-independent. GrpE binds as a homodimer to the ATPase domain of DnaK.nd may interact with the peptide-binding domain of DnaK. GrpE accomplishes nucleotide exchange by opening the nucleotide-binding cleft of DnaK. GrpE is comprised of two domains.he N-terminal coiled coil domain.hich may facilitate peptide release.nd the C-terminal head domain.hich forms part of the contact surface with the ATPase domain of DnaK. This entry represents the N-terminal coiled-coil domain.
  IPR013805:GrpE nucleotide exchange factor, coiled-coil
IPR005821:Ion_trans 
Evalue:-28.7212467193604 
Location:198-392IPR000595:cNMP 
Evalue:-24.7958800173441 
Location:475-599IPR013805:GrpE_coiled_coil 
Evalue:0 
Location:609-661
SequencesProtein: CNGA1_HUMAN (686 aa)
mRNA: NM_000087 S42457
Local Annotation
Synapse Ontology
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
LTP that is not dependent on the function of NMDA receptor.
sdb:0255 NMDA Receptor-independent LTP  (Evidence:domains)
K channel plays an important role in the course of action potential
sdb:0286 K channel  (Evidence:domains)
all kinds of ion channels that play their roles in the synaptic activity.
sdb:0308 ion channels and receptors  (Evidence:domains)
KO assignmentK04948
  Level 3 annotation:
    cyclic nucleotide gated channel alpha 1
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 618 residues, 47632750-47634603Exon2: 37 residues, 47637536-47637643Exon3: 38 residues, 47638814-47638922Exon4: 38 residues, 47639954-47640062Exon5: 16 residues, 47640144-47640186Exon6: 23 residues, 47646606-47646669Exon7: 41 residues, 47648126-47648243Exon8: 44 residues, 47649356-47649483Exon9: 2 residues, -Jump to CNGA1_HUMANExon1: 608 residues, 47632782-47634603Exon2: 37 residues, 47637536-47637643Exon3: 38 residues, 47638814-47638922Exon4: 38 residues, 47639954-47640062Exon5: 16 residues, 47640144-47640186Exon6: 23 residues, 47646606-47646669Exon7: 41 residues, 47648126-47648243Exon8: 42 residues, 47649356-47649477Exon9: 70 residues, 47667669-47667874Exon10: 49 residues, 47678166-47678307Exon11: 2 residues, -Jump to CNGA1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4674 47632750-47678307 ~-46K 27547(CNGA1)(-)Loci: 4673 47290776-47534816 ~-244K 27544(CORIN)(-)Link out to UCSC