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0CND3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCAPG
DescriptionCondensin complex subunit 3 (chromosome-associated protein g) (condensin subunit cap-g) (hcap-g) (xcap-g homolog) (ny-mel-3 antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (NAS)
0007076 mitotic chromosome condensation (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The HEAT repeat is a tandemly repeated.7-47 amino acid long moduleoccurring in a number of cytoplasmic proteins.ncluding the fourname-giving proteins huntingtin.longation factor 3 (EF3).he 65 Kdalpha regulatory subunit of protein phosphatase 2A (PP2A) and theyeast PI3-kinase TOR1 . Arrays of HEAT repeats consists of 3 to 36units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that manyHEAT repeat-containing proteins are involved in intracellular transport processes.In the crystal structure of PP2A PR65/A .he HEAT repeats consistof pairs of antiparallel alpha helices.s predicted in .
  IPR000357:HEAT
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR000357:HEAT 
Evalue:-0.30103000998497 
Location:137-173IPR000357:HEAT_REPEAT 
Evalue:0 
Location:0-0
SequencesProtein: CND3_HUMAN (1015 aa)
mRNA: NM_022346
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK06678
  Level 3 annotation:
    condensin complex subunit 3
  Level 2 annotation:
    Cell cycle
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 96 residues, 17421622-17421909Exon2: 70 residues, 17422941-17423145Exon3: 78 residues, 17423637-17423866Exon4: 50 residues, 17425573-17425719Exon5: 30 residues, 17425994-17426079Exon6: 66 residues, 17427981-17428174Exon7: 52 residues, 17428659-17428809Exon8: 49 residues, 17433703-17433844Exon9: 43 residues, 17434367-17434491Exon10: 32 residues, 17435688-17435778Exon11: 62 residues, 17436102-17436282Exon12: 39 residues, 17438998-17439109Exon13: 42 residues, 17441717-17441837Exon14: 77 residues, 17445019-17445244Exon15: 62 residues, 17447879-17448061Exon16: 60 residues, 17448347-17448522Exon17: 56 residues, 17450396-17450558Exon18: 48 residues, 17450791-17450930Exon19: 31 residues, 17451327-17451414Exon20: 25 residues, 17453030-17453100Exon21: 522 residues, 17454022-17455583Exon22: 2 residues, -Jump to CND3_HUMAN  
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Loci Cluster (Details)Loci: 3406 17421622-17455583 ~-34K 27407(CAPG)(+)Loci: 4666 17491890-17495261 ~-3K 27409(-)Loci: 4665 17097120-17122811 ~-26K 27403(QDPR)(-)Link out to UCSC