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0CMC1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC25A12
DescriptionCalcium-binding mitochondrial carrier protein aralar1 (mitochondrial aspartate glutamate carrier 1) (solute carrier family 25 member 12).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005739 mitochondrion (TAS)
0015294 cation symporter activity (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome . Such proteins include: ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally.hese proteins can consist of up to three tandem repeats of a domain of approximately 100 residues.ach domain containing two transmembrane regions.
  IPR001993:Mitochondrial substrate carrier
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP/ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varying degrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being about 100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R) {where - denotesany residue.nd Hy is a hydrophobic position} .
  IPR002067:Mitochondrial carrier protein
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (orcitrate transport protein); Graves disease carrier protein; yeastmitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varyingdegrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being ~100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R){where - denotesany residue.nd Hy is a hydrophobic position} .Mitochondrial ADP/ATP translocase.n abundant component of the innermembrane.arries ATP from the matrix into the inter-membrane space andtransports ADP back . The protein is an integral membrane protein thatfunctions as a homodimer.
  IPR002113:Adenine nucleotide translocator 1
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR001993:Mito_carr 
Evalue:-36.0506095886231 
Location:325-421IPR001993:Mito_carr 
Evalue:-35 
Location:517-609IPR001993:Mito_carr 
Evalue:-23.7695503234863 
Location:425-513IPR002048:efhand 
Evalue:-2.02687215805054 
Location:90-118IPR002048:efhand 
Evalue:-1.88605666160583 
Location:161-189IPR002048:EFh 
Evalue:1.25527250510331 
Location:56-84
SequencesProtein: CMC1_HUMAN (678 aa)
mRNA: NM_003705
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 369 residues, 172349126-172350231Exon2: 32 residues, 172352326-172352417Exon3: 55 residues, 172352544-172352703Exon4: 48 residues, 172356206-172356345Exon5: 49 residues, 172358382-172358523Exon6: 29 residues, 172374361-172374442Exon7: 19 residues, 172374979-172375032Exon8: 55 residues, 172378094-172378253Exon9: 29 residues, 172379876-172379958Exon10: 30 residues, 172391553-172391638Exon11: 33 residues, 172398718-172398812Exon12: 48 residues, 172399482-172399621Exon13: 51 residues, 172401876-172402023Exon14: 48 residues, 172409124-172409264Exon15: 40 residues, 172420589-172420705Exon16: 49 residues, 172433436-172433579Exon17: 20 residues, 172457960-172458014Exon18: 9 residues, 172458958-172458979Exon19: 2 residues, -Jump to CMC1_HUMAN  
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