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0CLPX_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCLPX
DescriptionAtp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0042623 ATPase activity, coupled (TAS)
0006457 protein folding (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This ATPase family.ssociated with various cellular activities.ncludes some of the AAA proteins not detected by .
  IPR013093:ATPase AAA-2
AAA ATPases form a large.unctionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases.hich exert their activity through the energy-dependent unfolding of macromolecules. AAA ATPases contain a P-loop NTPase domain.hich is the most abundant class of NTP-binding protein fold.nd is found throughout all kingdoms of life . P-loop NTPase domains act to hydrolyse the beta-gamma phosphate bond of bound nucleoside triphosphate. There are two classes of P-loop domains: the KG (kinase-GTPase) division.nd the ASCE division.he latter including the AAA+ group as well as several other ATPases.There are at least six major clades of AAA domains (metalloproteases.eiotic proteins.1 and D2 domains of ATPases with two AAA domains.roteasome subunits.nd BSC1).s well as several minor clades.ome of which consist of hypothetical proteins . The domain organisation of AAA ATPases consists of a non-ATPase N-terminal domain that acts in substrate recognition.ollowed by one or two AAA domains (D1 and D2).ne of which may be degenerate.
  IPR003593:AAA ATPase
ClpX is a member of the HSP (heat-shock protein) 100 family. Gel filtration and electron microscopy showed that ClpX subunits associate to form a six-membered ring that is stabilized by binding of ATP or nonhydrolyzable analogs of ATP . It functions as an ATP-depedent molecular chaperone and is the regulatory subunit of the ClpXP protease . ClpXP is involved in DNA damage repair.tationary-phase gene expression.nd ssrA-mediated protein quality control. To date more than 50 proteins include transcription factors.etabolic enzymes.nd proteins involved in the starvation and oxidative stress responses have been identified as substrates . The N-terminal domain of ClpX is a C4-type zinc binding domain (ZBD) involved in substrate recognition. ZBD forms a very stable dimer that is essential for promoting the degradation of some typical ClpXP substrates such as lO and MuA .
  IPR004487:ClpX, ATPase regulatory subunit
IPR013093:AAA_2 
Evalue:-60.5850257873535 
Location:284-503
SequencesProtein: CLPX_HUMAN (633 aa)
mRNA: NM_006660
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 156 residues, 63229837-63230304Exon2: 37 residues, 63231820-63231927Exon3: 33 residues, 63232937-63233030Exon4: 102 residues, 63234172-63234472Exon5: 57 residues, 63235082-63235247Exon6: 31 residues, 63236234-63236323Exon7: 57 residues, 63237136-63237301Exon8: 61 residues, 63237965-63238142Exon9: 16 residues, 63241994-63242036Exon10: 55 residues, 63243419-63243579Exon11: 53 residues, 63246021-63246176Exon12: 41 residues, 63258324-63258442Exon13: 55 residues, 63259434-63259595Exon14: 52 residues, 63264465-63264616Exon15: 2 residues, -Jump to CLPX_HUMAN  
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Loci Cluster (Details)Loci: 4176 63229837-63264616 ~-35K 12558(CLPX)(-)Loci: 4175 63081903-63109018 ~-27K 12552(MTFMT)(-)Link out to UCSC