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0CLK4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCLK4
DescriptionDual specificity protein kinase clk4 (ec 2.7.1.37) (ec 2.7.1.112) (cdc-like kinase 4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-82.0315170288086 
Location:159-475
SequencesProtein: CLK4_HUMAN (481 aa)
mRNA: CR749504 NM_020666
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00870
  Level 3 annotation:
    protein kinase
  Level 2 annotation:
    Signal transduction mechanisms
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 365 residues, 177962271-177963364Exon2: 32 residues, 177963450-177963541Exon3: 28 residues, 177964909-177964989Exon4: 29 residues, 177967982-177968065Exon5: 45 residues, 177972022-177972152Exon6: 33 residues, 177972402-177972497Exon7: 57 residues, 177973079-177973246Exon8: 41 residues, 177973333-177973450Exon9: 24 residues, 177976488-177976555Exon10: 32 residues, 177976950-177977041Exon11: 76 residues, 177978162-177978385Exon12: 55 residues, 177982862-177983023Exon13: 38 residues, 177986552-177986660Exon14: 2 residues, -Jump to CLK4_HUMANExon1: 163 residues, 177962877-177963364Exon2: 32 residues, 177963450-177963541Exon3: 28 residues, 177964909-177964989Exon4: 29 residues, 177967982-177968065Exon5: 45 residues, 177972022-177972152Exon6: 33 residues, 177972402-177972497Exon7: 57 residues, 177973079-177973246Exon8: 41 residues, 177973333-177973450Exon9: 24 residues, 177976488-177976555Exon10: 32 residues, 177976950-177977041Exon11: 76 residues, 177978162-177978385Exon12: 280 residues, 177979444-177980280Exon13: 24 residues, 177981999-177982066Exon14: 55 residues, 177982862-177983023Exon15: 30 residues, 177986552-177986636Exon16: 2 residues, -Jump to CLK4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4760 178337937-178354730 ~-17K 30083(GRM6)(-)Loci: 4759 177962271-177986660 ~-24K 30074(CLK4)(-)Link out to UCSC