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0CLK3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCLK3
DescriptionDual specificity protein kinase clk3 (ec 2.7.1.37) (ec 2.7.1.112) (cdc-like kinase 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004674 protein serine/threonine kinase activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-71.267606240177 
Location:156-472
SequencesProtein: CLK3_HUMAN (490 aa)
mRNA: NM_003992
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00870
  Level 3 annotation:
    protein kinase
  Level 2 annotation:
    Signal transduction mechanisms
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 19 residues, 72687765-72687820Exon2: 52 residues, 72698590-72698742Exon3: 74 residues, 72699402-72699619Exon4: 34 residues, 72701513-72701610Exon5: 24 residues, 72701887-72701954Exon6: 41 residues, 72704295-72704412Exon7: 57 residues, 72705195-72705362Exon8: 33 residues, 72706745-72706840Exon9: 45 residues, 72706932-72707062Exon10: 29 residues, 72707363-72707446Exon11: 28 residues, 72707997-72708077Exon12: 32 residues, 72708335-72708426Exon13: 138 residues, 72709100-72709510Exon14: 2 residues, -Jump to CLK3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4180 73034698-73036146 ~-1K 12752(-)Loci: 2900 73074953-73100889 ~-26K 12753(SCAMP5)(+)Loci: 2899 72687765-72709510 ~-22K 12733(CLK3)(+)Link out to UCSC