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0CLD11_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCLDN11
DescriptionClaudin-11 (oligodendrocyte specific protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (ISS)
0005923 tight junction (ISS)
0042802 protein self binding (ISS)
0016338 calcium-independent cell-cell adhesion (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Several vertebrate small integral membrane glycoproteins are evolutionary related .ncluding eye lens specific membrane protein 20 (MP20 or MP19); epithelial membrane protein-1 (EMP-1).hich is also known as tumor-associatedmembrane protein (TMP) or as squamous cell-specific protein Cl-20; epithelial membrane protein-2 (EMP-2).hich is also known as XMP; epithelial membrane protein-3 (EMP-3).lso known as YMP;and peripheral myelin protein 22 (PMP-22).hich is expressed in many tissues but mainly by Schwann cells as a component of myelin of the peripheral nervous system (PNS). PMP-22 probably plays a role both in myelinization and in cell proliferation. Mutations affecting PMP-22 are associated with hereditary motor and sensory neuropathies such as Charcot-Marie-Tooth disease type 1A (CMT-1A) in human or the trembler phenotype in mice. The proteins of this family are about 160 to 173 amino acid residues in size.nd contain four transmembrane segments. PMP-22.MP-1.2 and -3 are highly similar.hile MP20 is more distantly related. This family also includes the claudins.hich are components of tight junctions.
  IPR004031:PMP-22/EMP/MP20 and claudin
Zona occludens (ZO).r tight junctions (TJ).re specialised membrane domains found at the most apical region of polarised epithelial and endothelial cells that create a primary barrier.reventing paracellular transport of solutes.nd restricting the lateral diffusion of membrane lipids and proteins.hus maintaining cellular polarity . Under freeze-fracture electron microscopy.Js appear as a network of continuous anastomosing intramembranous strands. These strands consist mainly of claudins and occludin ().hich are transmembrane proteins that polymerise within plasma membranes to form fibrils . The claudin protein family is encoded by at least 17 human genes.ith many homologues cloned from other species. Tissue distribution patterns for the claudin family members are distinct. Claudin-1 and -2.or example.re expressed at high levels in the liver and kidney.hereas claudin-3 mRNA is detected mainly in the lung and liver . This suggests that multiple claudin family members may be involved in tight junction strand formation in a tissue-dependent manner. Hydropathy analysis suggests that all claudins share a common transmembrane (TM) topology. Each family member is predicted to possess four TM domains with intracellular N and C termini. Although their C-terminal cytoplasmic domain sequences vary.ost claudin family members share a common motif of -Y-V in this region. This has been postulated as a possible binding motif for PDZ domains of other tight junction-associated membrane proteins.uch as ZO-1 ().Claudin-11 was originally termed oligodendrocyte-specific protein (OSP). It was reclassified as claudin-11 due to its sequence similarity to claudins and its ability to form TJ strands in transfected fibroblasts. Claudin-11 expression is highly regulated during development and it has been postulated that it may play an important role in the growth and differentiation of oligodendrocytes and other cells outside the CNS .
  IPR003555:Claudin-11
Zona occludens (ZO).r tight junctions (TJ).re specialised membrane domains found at the most apical region of polarised epithelial and endothelial cells that create a primary barrier.reventing paracellular transport of solutes.nd restricting the lateral diffusion of membrane lipids and proteins.hus maintaining cellular polarity . Under freeze-fracture electron microscopy.Js appear as a network of continuous anastomosing intramembranous strands. These strands consist mainly of claudins and occludin ().hich are transmembrane proteins that polymerise within plasma membranes to form fibrils . The claudin protein family is encoded by at least 17 human genes.ith many homologues cloned from other species. Tissue distribution patterns for the claudin family members are distinct. Claudin-1 and -2.or example.re expressed at high levels in the liver and kidney.hereas claudin-3 mRNA is detected mainly in the lung and liver . This suggests that multiple claudin family members may be involved in tight junction strand formation in a tissue-dependent manner. Hydropathy analysis suggests that all claudins share a common transmembrane (TM) topology. Each family member is predicted to possess four TM domains with intracellular N and C termini. Although their C-terminal cytoplasmic domain sequences vary.ost claudin family members share a common motif of -Y-V in this region. This has been postulated as a possible binding motif for PDZ domains of other tight junction-associated membrane proteins.uch as ZO-1 ().
  IPR006187:Claudin tight junction protein
IPR004031:PMP22_Claudin 
Evalue:-14.0043649673462 
Location:4-176
SequencesProtein: CLD11_HUMAN (207 aa)
mRNA: NM_005602
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 139 residues, 171619358-171619774Exon2: 57 residues, 171623644-171623809Exon3: 526 residues, 171633005-171634577Exon4: 2 residues, -Jump to CLD11_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3383 171619358-171634577 ~-15K 26820(CLDN11)(+)Loci: 3382 171422918-171506458 ~-84K 26816(PRKCI)(+)Link out to UCSC