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0CLAP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCLASP2
DescriptionClip-associating protein 2 (cytoplasmic linker-associated protein 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The HEAT repeat is a tandemly repeated.7-47 amino acid long moduleoccurring in a number of cytoplasmic proteins.ncluding the fourname-giving proteins huntingtin.longation factor 3 (EF3).he 65 Kdalpha regulatory subunit of protein phosphatase 2A (PP2A) and theyeast PI3-kinase TOR1 . Arrays of HEAT repeats consists of 3 to 36units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that manyHEAT repeat-containing proteins are involved in intracellular transport processes.In the crystal structure of PP2A PR65/A .he HEAT repeats consistof pairs of antiparallel alpha helices.s predicted in .
  IPR000357:HEAT
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR000357:HEAT 
Evalue:-3.39793992042541 
Location:1097-1133IPR000357:HEAT 
Evalue:-3.19381999969482 
Location:1215-1251IPR011989:ARM-like 
Evalue:0 
Location:88-291IPR000357:HEAT_REPEAT 
Evalue:0 
Location:0-0
SequencesProtein: CLAP2_HUMAN (1294 aa)
mRNA: AB014527 NM_015097
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 825 residues, 33512741-33515213Exon2: 41 residues, 33518147-33518264Exon3: 71 residues, 33527053-33527260Exon4: 45 residues, 33532518-33532647Exon5: 66 residues, 33533476-33533670Exon6: 78 residues, 33551728-33551957Exon7: 53 residues, 33555284-33555438Exon8: 37 residues, 33559928-33560035Exon9: 50 residues, 33561193-33561337Exon10: 50 residues, 33567747-33567891Exon11: 28 residues, 33575802-33575881Exon12: 56 residues, 33577303-33577467Exon13: 24 residues, 33587219-33587286Exon14: 83 residues, 33589605-33589850Exon15: 37 residues, 33592664-33592771Exon16: 38 residues, 33598316-33598424Exon17: 59 residues, 33601245-33601416Exon18: 36 residues, 33608890-33608992Exon19: 8 residues, 33611446-33611464Exon20: 10 residues, 33613206-33613230Exon21: 60 residues, 33619447-33619621Exon22: 20 residues, 33620649-33620705Exon23: 58 residues, 33623086-33623254Exon24: 28 residues, 33623879-33623957Exon25: 22 residues, 33625062-33625122Exon26: 25 residues, 33628496-33628567Exon27: 47 residues, 33636098-33636234Exon28: 50 residues, 33638630-33638776Exon29: 33 residues, 33643483-33643576Exon30: 28 residues, 33648787-33648867Exon31: 51 residues, 33661252-33661399Exon32: 25 residues, 33679940-33680011Exon33: 34 residues, 33700854-33700952Exon34: 27 residues, 33703555-33703631Exon35: 32 residues, 33704772-33704864Exon36: 36 residues, 33706324-33706428Exon37: 28 residues, 33713350-33713429Exon38: 185 residues, 33734303-33734852Exon39: 2 residues, -Jump to CLAP2_HUMANExon1: 576 residues, 33513488-33515213Exon2: 41 residues, 33518147-33518264Exon3: 71 residues, 33527053-33527260Exon4: 45 residues, 33532518-33532647Exon5: 66 residues, 33533476-33533670Exon6: 78 residues, 33551728-33551957Exon7: 53 residues, 33555284-33555438Exon8: 37 residues, 33559928-33560035Exon9: 50 residues, 33561193-33561337Exon10: 50 residues, 33567747-33567891Exon11: 28 residues, 33575802-33575881Exon12: 56 residues, 33577303-33577467Exon13: 24 residues, 33587219-33587286Exon14: 83 residues, 33589605-33589850Exon15: 37 residues, 33592664-33592771Exon16: 23 residues, 33593697-33593760Exon17: 38 residues, 33598316-33598424Exon18: 59 residues, 33601245-33601416Exon19: 36 residues, 33608890-33608992Exon20: 8 residues, 33611446-33611464Exon21: 10 residues, 33613206-33613230Exon22: 60 residues, 33619447-33619621Exon23: 20 residues, 33620649-33620705Exon24: 58 residues, 33623086-33623254Exon25: 28 residues, 33623879-33623957Exon26: 22 residues, 33625062-33625122Exon27: 25 residues, 33628496-33628567Exon28: 47 residues, 33636098-33636234Exon29: 50 residues, 33638630-33638776Exon30: 33 residues, 33643483-33643576Exon31: 28 residues, 33648787-33648867Exon32: 51 residues, 33661252-33661399Exon33: 37 residues, 33675469-33675576Exon34: 2 residues, -Jump to CLAP2_HUMAN  
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Loci Cluster (Details)Loci: 3344 33814560-33886198 ~-72K 25375(PDCD6IP)(+)Loci: 4591 33512741-33734852 ~-222K 25373(CLASP2)(-)Link out to UCSC