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0CLAP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCLASP1
DescriptionClip-associating protein 1 (cytoplasmic linker-associated protein 1) (multiple asters homolog 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005875 microtubule associated complex (NAS)
0008017 microtubule binding (NAS)
0007026 negative regulation of microtubule depolyme... (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The HEAT repeat is a tandemly repeated.7-47 amino acid long moduleoccurring in a number of cytoplasmic proteins.ncluding the fourname-giving proteins huntingtin.longation factor 3 (EF3).he 65 Kdalpha regulatory subunit of protein phosphatase 2A (PP2A) and theyeast PI3-kinase TOR1 . Arrays of HEAT repeats consists of 3 to 36units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that manyHEAT repeat-containing proteins are involved in intracellular transport processes.In the crystal structure of PP2A PR65/A .he HEAT repeats consistof pairs of antiparallel alpha helices.s predicted in .
  IPR000357:HEAT
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR000357:HEAT 
Evalue:-7.67778062820435 
Location:162-198IPR000357:HEAT 
Evalue:-3.12493872642517 
Location:1460-1495IPR000357:HEAT 
Evalue:-2.76955103874207 
Location:1341-1377IPR000357:HEAT 
Evalue:-0.0222763940691948 
Location:439-475
SequencesProtein: CLAP1_HUMAN (1538 aa)
mRNA: NM_015282
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1057 residues, 121811824-121814993Exon2: 41 residues, 121821083-121821200Exon3: 71 residues, 121822557-121822764Exon4: 45 residues, 121837217-121837346Exon5: 65 residues, 121839139-121839330Exon6: 83 residues, 121841633-121841877Exon7: 52 residues, 121851544-121851695Exon8: 41 residues, 121856253-121856370Exon9: 37 residues, 121861167-121861274Exon10: 50 residues, 121861808-121861952Exon11: 50 residues, 121871185-121871329Exon12: 28 residues, 121872367-121872446Exon13: 56 residues, 121875554-121875718Exon14: 24 residues, 121878413-121878480Exon15: 83 residues, 121881516-121881761Exon16: 36 residues, 121884911-121885015Exon17: 38 residues, 121892667-121892775Exon18: 58 residues, 121899184-121899352Exon19: 11 residues, 121901449-121901476Exon20: 37 residues, 121904118-121904223Exon21: 59 residues, 121921382-121921553Exon22: 18 residues, 121922321-121922371Exon23: 58 residues, 121922998-121923166Exon24: 28 residues, 121924958-121925036Exon25: 22 residues, 121925835-121925895Exon26: 25 residues, 121931732-121931803Exon27: 47 residues, 121932885-121933021Exon28: 50 residues, 121934025-121934171Exon29: 33 residues, 121935146-121935239Exon30: 26 residues, 121936577-121936651Exon31: 53 residues, 121943853-121944006Exon32: 24 residues, 121977212-121977280Exon33: 34 residues, 121989710-121989808Exon34: 27 residues, 121999890-121999966Exon35: 32 residues, 122001844-122001936Exon36: 36 residues, 122002722-122002826Exon37: 28 residues, 122004292-122004371Exon38: 162 residues, 122079746-122080226Exon39: 37 residues, 122123417-122123522Exon40: 2 residues, -Jump to CLAP1_HUMAN  
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Loci Cluster (Details)Loci: 4461 122201023-122210938 ~-10K 21205(MKI67IP)(-)Loci: 4460 121811824-122123522 ~-312K 21204(CLASP1)(-)Link out to UCSC