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0CK5P1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCDK5RAP1
DescriptionCdk5 regulatory subunit-associated protein 1 (cdk5 activator-binding protein c42).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0042808 neuronal Cdc2-like kinase binding (NAS)
0005515 protein binding (IPI)
0007420 brain development (NAS)
0008283 cell proliferation (ISS)
0045736 negative regulation of cyclin dependent pro... (IDA)
0045664 regulation of neuron differentiation (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry represents an N-terminal domain found in a family of proteins defined by sequence similarity. Most of these proteins are not yet characterised.ut those that are includeCDK5 regulatory subunit-associated protein 1.hich specifically inhibits CDK5 activation by CDK5R1 .MiaB. tRNA modification enzyme . It is almost always found in conjunction with a radical SAM domain () and a TRAM domain ().
  IPR013848:Protein of unknown function UPF0004, N-terminal
This domain is found in MoaA.ifB.qqE.oproporphyrinogenIII oxidase.iotin synthase and MiaB families.nd includes a representative in the eukaryotic elongatorsubunit.lp-3. Some members of the family are methyltransferases .
  IPR006638:Elongator protein 3/MiaB/NifB
Radical SAM proteins catalyze diverse reactions.ncluding unusual methylations.somerization.ulphur insertion.ing formation.naerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S:-adenosylmethionine (SAM) through an unusual Fe-S center .
  IPR007197:Radical SAM
The TRAM (after TRM2 and miaB) domain is a 60-70-residue-long module that is found in:Two distinct classes of tRNA-modifying enzymes.amely uridine methylases of the TRM2 family and enzymes of the miaB family that are involved in 2- methylthioadenine formationIn several other proteins associated with the translation machineryIn a family of small uncharacterized archaeal proteins that are predicted to have a role in the regulation of tRNA modification and/or translationThe TRAM domain can be found alone or in association with other domains.uch as the catalytic biotin/lipoate synthetase-like domain.he RNA methylase domain.he ribosomal S2 domain and the eIF2-beta domain. The TRAM domain is predicted to bind tRNA and deliver the RNA-modifying enzymatic domain to their targets .Secondary structure prediction indicates that the TRAM domain adopts a simple beta-barrel fold. The conservation pattern of the TRAM domain consists primarily of small and hydrophobic residues that correspond to five beta-strands in the predicted secondary structure .
  IPR002792:Deoxyribonuclease/rho motif-related TRAM
This entry represents a family defined on the basis of sequence similarity. Most of these proteins are not yet characterised.ut those that are includeCDK5 regulatory subunit-associated protein 1.hich specifically inhibits CDK5 activation by CDK5R1 .MiaB. tRNA modification enzyme . The size of proteins in this entry ranges from 47 to 61 kDa and they contain six conserved cysteines.hree of which are clustered.
  IPR005839:Protein of unknown function UPF0004
These sequences are homologs of the MiaB enzyme responsible for the modification of the isopentenylated adenine-37 base of most bacterial and eukaryotic tRNAs that read codons beginning with uracil (all except tRNA(I.) Ser). Adenine-37 is next to the anticodon on the 3 side in these tRNAs.nd lack of modification at this site leads to an increased spontaneous mutation frequency. Isopentenylated A-37 is modified by methylthiolation at position 2.ither by MiaB alone or in concert with a separate methylase yet to be discovered (MiaC?) .
  IPR006463:tRNA-i(6)A37 modification enzyme MiaB
IPR013848:UPF0004 
Evalue:-50.1307678222656 
Location:101-204IPR006638:Elp3 
Evalue:-47.7447274948967 
Location:248-501IPR002792:TRAM 
Evalue:-8 
Location:515-590
SequencesProtein: CK5P1_HUMAN (601 aa)
mRNA: NM_016408
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 96 residues, 31410305-31410590Exon2: 49 residues, 31411817-31411958Exon3: 51 residues, 31418325-31418472Exon4: 45 residues, 31421965-31422096Exon5: 20 residues, 31424108-31424164Exon6: 34 residues, 31425581-31425679Exon7: 79 residues, 31430927-31431158Exon8: 42 residues, 31437116-31437237Exon9: 72 residues, 31438789-31439000Exon10: 35 residues, 31443608-31443709Exon11: 13 residues, 31445498-31445533Exon12: 36 residues, 31446479-31446583Exon13: 110 residues, 31448227-31448551Exon14: 32 residues, 31452894-31452986Exon15: 2 residues, -Jump to CK5P1_HUMANExon1: 96 residues, 31410305-31410590Exon2: 49 residues, 31411817-31411958Exon3: 52 residues, 31418325-31418475Exon4: 45 residues, 31421965-31422096Exon5: 20 residues, 31424108-31424164Exon6: 34 residues, 31425581-31425679Exon7: 79 residues, 31430927-31431158Exon8: 42 residues, 31437116-31437237Exon9: 72 residues, 31438789-31439000Exon10: 35 residues, 31443608-31443709Exon11: 13 residues, 31445498-31445533Exon12: 36 residues, 31446479-31446583Exon13: 110 residues, 31448227-31448551Exon14: 36 residues, 31452894-31452998Exon15: 2 residues, -Jump to CK5P1_HUMAN  
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Loci Cluster (Details)Loci: 4516 31459423-31495359 ~-36K 22912(SNTA1)(-)Loci: 4517 31727149-31737854 ~-11K 22925(E2F1)(-)Loci: 3247 31862779-31905830 ~-43K 22928(CHMP4B)(+)Loci: 4515 31410305-31452998 ~-43K 22906(CDK5RAP1)(-)Link out to UCSC