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0CJ118_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionProtein c10orf118 (ctcl tumor antigen hd-cl-01/l14-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Soluble N-ethylmaleimide attachment protein receptor (SNARE) proteins are a family of membrane-associated proteins characterised by an alpha-helical coiled-coil domain called the SNARE motif . These proteins are classified as v-SNAREs and t-SNAREs based on their localisation on vesicle or target membrane; another classification scheme defines R-SNAREs and Q-SNAREs.s based on the conserved arginine or glutamine residue in the centre of the SNARE motif. SNAREs are localised to distinct membrane compartments of the secretory and endocytic trafficking pathways.nd contribute to the specificity of intracellular membrane fusion processes.The t-SNARE domain consists of a 4-helical bundle with a coiled-coil twist. The SNARE motif contributes to the fusion of two membranes. SNARE motifs fall into four classes: homologues of syntaxin 1a (t-SNARE).AMP-2 (v-SNARE).nd the N- and C-terminal SNARE motifs of SNAP-25. It is thought that one member from each class interacts to form a SNARE complex.The SNARE motif represented in this entry is found in the N-terminal domains of certain syntaxin family members: syntaxin 1a.hich is required for neurotransmitter release.yntaxin 6.hich is found in endosomal transport vesicles .east Sso1p .nd Vam3p. yeast syntaxin essential for vacuolar fusion . The SNARE motifs in these proteins share structural similarity.espite having a low level of sequence similarity.
InterPro domains unassigned to SynO:
The tRNA-binding arm domain is conserved between class I and class II enzymes.onsisting of two alpha helices in an antiparallel hairpin with a left-handed twist. The appended tRNA-binding domains recognize a small number of nucleotides that are conserved specifically in each cognate tRNA species for the discrimination between the cognate and noncognate tRNAs . These nucleotides are called identity elements.nd constitute the identity set. The tRNA-binding arm occurs as the C-terminal domain in some class I enzymes.uch as valyl-tRNA synthetase.nd as the N-terminal domain in some class II enzymes.uch as phenylalanyl-tRNA synthetase.The methicillin resistance protein.emA (factors essential for methicillin resistance).ontains a probable tRNA-binding arm that is similar in structure to those found in tRNA synthetases. In FemA.he tRNA-binding arm is inserted into the C-terminal NAT-like domain.nd is thought to bind tRNA-glycine. FemA.long with FemB and FemX.lays a vital role in peptidoglycan biosynthesis specific to Staphylococci .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR010978:tRNA-binding arm
In prokaryotes.he nucleotide exchange factor GrpE and the chaperone DnaJ are required for nucleotide binding of the molecular chaperone DnaK . The DnaK reaction cycle involves rapid peptide binding and release.hich is dependent upon nucleotide binding. DnaJ accelerates the hydrolysis of ATP by DnaK.hich enables the ADP-bound DnaK to tightly bind peptide. GrpE catalyses the release of ADP from DnaK.hich is required for peptide release. In eukaryotes.rpE is essential for mitochondrial Hsp70 function.owever the cytosolic Hsp70 homologues are GrpE-independent. GrpE binds as a homodimer to the ATPase domain of DnaK.nd may interact with the peptide-binding domain of DnaK. GrpE accomplishes nucleotide exchange by opening the nucleotide-binding cleft of DnaK. GrpE is comprised of two domains.he N-terminal coiled coil domain.hich may facilitate peptide release.nd the C-terminal head domain.hich forms part of the contact surface with the ATPase domain of DnaK. This entry represents the N-terminal coiled-coil domain.
  IPR013805:GrpE nucleotide exchange factor, coiled-coil
SequencesProtein: CJ118_HUMAN (898 aa)
mRNA: NM_018017
Local Annotation
Synapse Ontology
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:domains)
sdb:0328 transmitters release and endocytosis  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1005 residues, 115871963-115874975Exon2: 75 residues, 115875634-115875854Exon3: 72 residues, 115877209-115877420Exon4: 29 residues, 115879639-115879720Exon5: 65 residues, 115880895-115881085Exon6: 87 residues, 115881677-115881933Exon7: 49 residues, 115884661-115884804Exon8: 31 residues, 115885639-115885726Exon9: 35 residues, 115885896-115885995Exon10: 37 residues, 115886934-115887039Exon11: 42 residues, 115894245-115894365Exon12: 73 residues, 115895297-115895510Exon13: 45 residues, 115900840-115900969Exon14: 44 residues, 115907302-115907429Exon15: 233 residues, 115912385-115913078Exon16: 199 residues, 115923763-115924354Exon17: 2 residues, -Jump to CJ118_HUMAN  
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