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0CISY_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCS
DescriptionCitrate synthase, mitochondrial precursor (ec 2.3.3.1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004108 citrate (Si)-synthase activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Citrate synthase is a member of a small family of enzymes that can directlyform a carbon-carbon bond without the presence of metal ion cofactors .It catalyses the first reaction in the Krebs cycle :acetyl-CoA + H2O + oxaloacetate = citrate + CoAThis reaction is an an important function in both energy generation and carbon assimilation .The reaction proceeds via a non-covalently bound intermediate citryl-coenzyme A intermediate.nd is thus thought to be a 2-step process . The enzyme exists as a globular homodimer (a hexamer in prokaryotes).hich is almost completely helical (20 helices per monomer).hich is unusual forsuch a large enzyme . Ineukaryotes.here are two isozymes of citrate synthase: one is found in themitochondrial matrix.he second is cytoplasmic. Both seem to be dimers ofidentical chains. Each monomer is divided into a large and a small domain.he cleft between these domains forming the active site where both citrate and acetyl-coenzyme A have been shown to bind . The enzymeundergoes a conformational change upon binding of the oxaloacetate.herebythe active site cleft closes over .There are a number of regions of sequence similarity between prokaryotic andeukaryotic citrate synthases. One of the best conserved contains a histidinewhich is one of three residues shown to be involved in the catalyticmechanism of the vertebrate mitochondrial enzyme.
  IPR002020:Citrate synthase
This entry includes both mitochondrial and peroxisomal forms of citrate synthase. Citrate synthase is the entry point to the TCA cycle from acetyl-CoA. Peroxisomal forms.ecognized by the C-terminal targeting motif SKL.ct in the glyoxylate cycle. Eukaryotic homologs include a Tetrahymena thermophila citrate synthase that doubles as a filament protein. putative citrate synthase from Plasmodium falciparum (no TCA cycle).nd a methylcitrate synthase from Aspergillus nidulans.
  IPR010109:Citrate synthase, eukaryotic
IPR002020:Citrate_synt 
Evalue:-232.200653076172 
Location:71-449
SequencesProtein: CISY_HUMAN (466 aa)
mRNA: NM_004077 NM_198324
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01647
  Level 3 annotation:
    citrate synthase
  Level 2 annotation:
    Citrate cycle (TCA cycle)
    Glyoxylate and dicarboxylate metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 519 residues, 54951749-54953305Exon2: 72 residues, 54953637-54953847Exon3: 36 residues, 54954827-54954929Exon4: 45 residues, 54955052-54955182Exon5: 68 residues, 54956046-54956246Exon6: 65 residues, 54962470-54962659Exon7: 46 residues, 54962910-54963042Exon8: 24 residues, 54963842-54963908Exon9: 38 residues, 54965966-54966074Exon10: 19 residues, 54966645-54966696Exon11: 29 residues, 54978659-54978742Exon12: 79 residues, 54980210-54980442Exon13: 2 residues, -Jump to CISY_HUMANExon1: 519 residues, 54951749-54953305Exon2: 72 residues, 54953637-54953847Exon3: 36 residues, 54954827-54954929Exon4: 45 residues, 54955052-54955182Exon5: 68 residues, 54956046-54956246Exon6: 65 residues, 54962470-54962659Exon7: 46 residues, 54962910-54963042Exon8: 24 residues, 54963842-54963908Exon9: 38 residues, 54965966-54966074Exon10: 19 residues, 54966645-54966696Exon11: 79 residues, 54980210-54980442Exon12: 2 residues, -Jump to CISY_HUMAN  
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Loci Cluster (Details)Loci: 2763 54396087-54399754 ~-4K 9024(BLOC1S1)(+)Loci: 2764 54423333-54430331 ~-7K 9030(GDF11)(+)Loci: 2765 54654128-54674745 ~-21K 9056(RAB5B)(+)Loci: 2766 54677309-54685574 ~-8K 9057(SUOX)(+)Loci: 2767 54798296-54802545 ~-4K 9067(+)Loci: 4051 54843395-54869544 ~-26K 9082(SMARCC2)(-)Loci: 4052 54951749-54980442 ~-29K 9095(CS)(-)Loci: 4053 55151003-55168448 ~-17K 9108(GLS2)(-)Loci: 4054 55275981-55316430 ~-40K 9114(BAZ2A)(-)Loci: 4055 55318225-55326119 ~-8K 9115(ATP5B)(-)Loci: 4056 55708568-55730160 ~-22K 9128(MYO1A)(-)Loci: 4050 54364622-54387894 ~-23K 9022(ITGA7)(-)Link out to UCSC